SERUM/PLASMA LEVELS OF ZINC IN TYPE 2 DIABETIC SUBJECTS VERSUS HEALTHY SUBJECTS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Background and objectives: Type 2 diabetes mellitus (T2DM) is one of the leading chronic diseases worldwide. Zinc plays an important role in glucose metabolism, joining in the synthesis, storage, secretion and action of insulin. A large number of studies have compared serum/plasma levels of zinc in...

Full description

Saved in:
Bibliographic Details
Published in:Annals of nutrition and metabolism 2017-10, Vol.71 (Suppl. 2), p.883
Main Authors: Cao, José Cándido Fernández, Warthon-Medina, Marisol, Moran, Victoria Hall, Arija, Victoria, Serra-Majem, Lluis, Lowe, Nicola M
Format: Article
Language:English
Subjects:
Bias
Chronic illnesses
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Exploration
Glucose metabolism
Heterogeneity
Insulin
Meta-analysis
Metabolism
Plasma
Plasma levels
Prospero protein
Reviews
Secretion
Zinc
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and objectives: Type 2 diabetes mellitus (T2DM) is one of the leading chronic diseases worldwide. Zinc plays an important role in glucose metabolism, joining in the synthesis, storage, secretion and action of insulin. A large number of studies have compared serum/plasma levels of zinc in subjects with T2DM vs. nondiabetic subjects, but their results are inconclusive. This systematic review and meta-analysis aimed to compare serum/plasma levels of zinc in type 2 diabetic subjects without complications vs. healthy subjects. Methods: This study has been registered in Prospero (2015: CRD42015020178). A robust search developed in the EURRECA Network was performed at Embase, Pubmed/Medline, and The Cochrane Library until March 16, 2016. Studies were selected if a) they had an observational design, b) were performed on subjects >18 years, c) had data on the mean and standard deviation of serum/plasma levels of zinc in both type 2 diabetic subjects without complications and nondiabetic subjects. Animal/lab studies, studies with diabetic participants other than T2DM, and study designs other than cross-sectional, case-control and prospective cohort studies were excluded. Potentially relevant articles for the systematic review and meta-analysis were selected for full exploration. Data are expressed as mean differences (MD) with 95% CIs, using the generic inverse-variance random-effects model. Heterogeneity was assessed by the Cochran Q-statistic and quantified by the I2 statistic (significance P
ISSN:0250-6807
1421-9697
DOI:10.1159/000480486