AMELIORATED EFFECTS OF ETHANOL EXTRACTS FROM CAJANUS CAJAN (L.) MILLSP. ROOTS ON METHYLGLYOXAL-INDUCED INSULIN RESISTANCE IN RATS

Background and objectives: Cajanus cajan (L.) Millsp. root cooked with the ribs can cure diabetes is recognized an aboriginal traditional therapies in Taiwan. Previous studies known after a series of separation and purification from ethanol extract of C. cajan root was obtained Betulinic acid, bioch...

Full description

Saved in:
Bibliographic Details
Published in:Annals of nutrition and metabolism 2017-10, Vol.71 (Suppl. 2), p.1178
Main Authors: Song, Tuzz-Ying, Lin, Yen-Fong, Chen, Chien-Lin, Thi, Thuy-Lan Vo, Hsu, Min-Yen
Format: Article
Language:English
Subjects:
Advanced glycosylation end products
Antioxidants
Attenuation
Betulinic acid
Biochanin A
Cajanus cajan
Carbohydrates
Diabetes mellitus
Ethanol
Flavonoids
Food intake
Genistein
Glucose
Glucose tolerance
Hemoglobin
Hip
Hypoglycemia
Insulin
Insulin resistance
Liver
Malondialdehyde
Metformin
Oxidation resistance
Purification
Pyruvaldehyde
Rats
Rodents
Roots
Sensitivity
Sugar
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and objectives: Cajanus cajan (L.) Millsp. root cooked with the ribs can cure diabetes is recognized an aboriginal traditional therapies in Taiwan. Previous studies known after a series of separation and purification from ethanol extract of C. cajan root was obtained Betulinic acid, biochanin A, 5,2'-dihydroxy-7,4'-dimethoxyisoflavanone (cajanol), genistein, 2'-hydroxygenistein and other differences flavonoids. Many studies have confirmed the above components such as: genistein has excellent antioxidant capacity and the ability to inhibit the decomposition of carbohydrates. Methods: We investigated whether ethanol extracts of C. cajan roots (EECR) could protect against methylglyoxal (MGO; 500 mg/kg bw)-induced insulin resistance (IR) in male Wistar rats between days 1 to 84. Rats treated with MGO were used to examine the hypoglycemic effects of EECR. The rats were divided into six groups and orally supplemented with MGO except for group 1 (normal controls). Group 3 was orally supplemented with Metformin (hypoglycemic drugs) (MET;10 mg/kg bw), group 4 with EECR-L (10 mg/kg bw), group 5 with HIP EECR-M (50 mg/kg bw), and group 6 with EECR-H (100 mg/kg bw). MET and EECR were provided daily between days 21 to 84 in rats. Oral glucose tolerance (OGTT) and insulin tolerance (ITT) tests in 6 groups were evaluated every 2 weeks. Results: The results indicated that body weights, water and food intake for each group revealed no significant difference (P>0.05). In ITT tests, serum glucose levels of MGO-treated group were slightly change during 120 min (no insulin sensitivity) after intraperitoneal injection of insulin, however, L-, M- and H-EECR-treated rats significantly increased insulin sensitivity (P
ISSN:0250-6807
1421-9697
DOI:10.1159/000480486