INTAKE OF FATTY ACIDS AND ITS CORRELATION WITH RENAL FUNCTION IN CHILDREN WITH OVERWEIGHT/OBESITY

• Published in: Annals of nutrition and metabolism 2017-10, Vol.71 (Suppl. 2), p.941
• Main Authors: Peredo, Maria Soledad, Scricciolo, Romina, Alonso, Elizabeth, Lando, Inés, Brovarone, Lucrecia, Fernández, Jorgelina, Muzzio, María Luz, Santucci, Maria Pia, Meroño, Tomas, Kabakian, Maria Laura
• Format: Article
• Language: English
• Subjects: Anthropometry; Body weight; Children; Children & youth; Correlation; Correlation analysis; Creatinine; Diabetes mellitus; Dietary supplements; Fatty acids; Glomerular filtration rate; Inflammation; Lipids; Longitudinal studies; Mathematical analysis; Micronutrients; Nutrition assessment; Obesity; Overweight; Peroxisome proliferator-activated receptors; Polyunsaturated fatty acids; Receptors; Renal function; Serum lipids
• ISSN: 0250-6807; 1421-9697
• DOI: 10.1159/000480486

Background and objectives: Polyunsaturated fatty acids (PUFA) are defined as the sum of ...3 and ...6-fatty acids (FA). Their impacts on health are mainly attributed to anti-inflammatory effects and to the activation of the peroxisome proliferator-activated receptors(PPAR)-γ. In dietary interventions for obesity the substitution of saturated fatty acids (SFA) by PUFA is encouraged. Only few studies addressed the impact of PUFA intake over the glomerular filtration rate (GFR) in patients without renal disease. Our aim was to evaluate the association between dietary FA and GFR in children with overweight/obesity. Methods: Prospective study which included 35 children [age: 11(9-13)years] with overweight/obesity who attended the "Servicio de Diabetes y Nutricion Infanto-Juvenil" of the "Complejo Medico Churruca-Visca", Buenos Aires, Argentina. Anthropometric measures were determined and Z-scores were calculated (WHO). Nutritional assessment was performed by the 24-hour dietary recall method using the tables from the "Sistema de Analisis y Registros Alimentarios" (SARA, Ministerio de Salud). GFR was estimated using the Zappitelli formula using serum creatinine and cistatin C levels. Serum lipids and levels of selected micronutrients were recorded. Correlations were evaluated by Pearson or Spearman Correlation tests, according to data distribution. Results: Out of the 35 children studied (18 males), 25 were obese and 10 were overweight. Mean BMI Z-score was 1.9±0.5. None of the children were taking dietary supplements. Median intake of SFA, monounsaturated fatty acids (MUFA) and PUFA were, median(interquartile range), 14.1(10.2-24.7)g/day, 17.6(11.3-20.7) g/day and 4.5(1.9-10.0)g/day, respectively. Mean GFR was 97±15 ml/min.1.73m2. Intakes of SFA and MUFA were only correlated with waist circumference (r=0.36,p