Prediction of electron density and trace element concentrations in human blood serum following radioiodine therapy in differentiated thyroid cancer patients

• Published in: Measurement : journal of the International Measurement Confederation 2017-03, Vol.100, p.19-25
• Main Authors: Bursalıoğlu, Ertuğrul O., Alkan, Fatma A., Barutçu, Ümit B., Demir, Mustafa, Karabul, Yaşar, Balkan, Begüm, Öz, Ersoy, İçelli, Orhan
• Format: Article
• Language: English
• Subjects: Blood; Blood samples; Cancer; Copper; Electron density; Elements; ICP-OES; Iodine 131; Iron; Magnesium; Manganese; Minerals; Patients; Pretreatment; Selenium; Statistical analysis; Statistical methods; Therapy; Thyroid cancer; Trace elements; Zinc
• ISSN: 0263-2241; 1873-412X
• DOI: 10.1016/j.measurement.2016.12.035

The aim of this study is to investigate element levels (Cr, Cu, Fe, Mg, Mn, Se, Zn, As, B, Si and Co) in blood samples of patients with thyroid cancer. In literature, these elements levels were measured for different types of cancer. In addition, the concentrations of elements were normalized to percent. Later, Electron densities of blood samples have been determined by means of ZXCOM program. An attempt was made to establish a correlation between electron density and pre-posttreatment. Also, according to statistical analysis of the blood results from 11 patients and 11 control group for pre-posttreatment, it can be concluded that the treatment can changes the value of Cr, Fe, Mn and Co. [Display omitted] •The element levels have been calculated in blood samples of patients with thyroid cancer.•Calculating electron densities of with ZXCOM program blood samples posttreatment are bigger than pretreatment.•The elemental analysis of blood samples has been carried out using ICP-OES.•An attempt was made to establish a correlation between electron density (Neff) and pre-posttreatment.•Electron density has an increasing pattern in the post-treatment group about changing the value of Cr, Fe, Mn and Co. The aim of this study is to investigate trace element levels (Cr, Cu, Fe, Mg, Mn, Se, Zn, As, B, Si and Co) in serum samples of patients with papillary thyroid cancer. The analysis of trace elements levels of samples carried out using ICP-OES. Elements in blood samples were determined by ICP-OES after using Hettich Universal Centrifuge and differences between the values of Zn, Mg, Fe and Cu of blood samples were obtained pre-therapy and post-therapy. The concentrations of elements were normalized to percentage. Later, electron densities (Nel) of blood samples have been determined using ZXCOM program. A venture was made to perform a correlation between electron density and pre-posttreatment. This attempt is quite new in literature. Interestingly, it was generally observed that the electron densities of blood samples posttreatment are higher than pretreatment. Among elements, normalized concentration values of Cu and electron densities were in particular compared with patient type. Also, statistical analysis of blood results was achieved for 11 patients and 11 normal individual as control group for pre-posttreatment. Wilcoxon test which is a non-parametric test was used.