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A lateral flow channel immunoassay combining a particle binding zone geometry with nanoparticle labelling amplification
•Channel flow design with reaction area: sample volume >20 times the open channel immunoassay format.•Simple channel flow design for samples of ≥10 μL.•Reaction zone of silica particles with covalently linked capture antibodies, combined with non-direct fluorescent nanoparticles.•Strong fluoresce...
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Published in: | Sensors and actuators. B, Chemical Chemical, 2018-06, Vol.262, p.1-8 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •Channel flow design with reaction area: sample volume >20 times the open channel immunoassay format.•Simple channel flow design for samples of ≥10 μL.•Reaction zone of silica particles with covalently linked capture antibodies, combined with non-direct fluorescent nanoparticles.•Strong fluorescent signal generated from fluorescent pre-cursor particles.•Model system of RbIgG/Gt-α RbIgG showed good linearity for detection of |
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ISSN: | 0925-4005 1873-3077 |
DOI: | 10.1016/j.snb.2018.01.213 |