H1N1 pneumonitis treated with intravenous zanamivir

In view of high volume gastric aspirates, we used nebulised zanamivir. Since her infl amed, atelectatic lungs were probably im peding adequate drug absorption, and clinical improve ment was not forth coming, we used intravenous (un licensed) zanamivir.

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Bibliographic Details
Published in:The Lancet (British edition) 2009-09, Vol.374 (9694), p.1036-1036
Main Authors: Kidd, I Michael, Dr, Down, Jim, FRCA, Nastouli, Eleni, FRCPath, Shulman, Rob, DHCPharm, Grant, Paul R, PhD, Howell, David CJ, MRCP, Singer, Mervyn, FRCP
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adult
Anti-Inflammatory Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial agents
Antiviral agents
Antiviral Agents - therapeutic use
Biological and medical sciences
Bronchoalveolar Lavage Fluid - virology
Case reports
Chemotherapy
Critical Care - methods
Drug Administration Schedule
Drug therapy
Drug Therapy, Combination
Female
General aspects
Hodgkin Disease - drug therapy
Humans
Immunocompromised Host
Influenza A Virus, H1N1 Subtype
Infusions, Intravenous
Internal Medicine
Intravenous administration
Laboratories
Laboratory tests
Medical research
Medical sciences
Methylprednisolone - therapeutic use
Neutropenia - chemically induced
Neutropenia - complications
Pandemics
Pharmacology. Drug treatments
Pneumonia
Pneumonia, Viral - diagnosis
Pneumonia, Viral - drug therapy
Pneumonia, Viral - immunology
Pneumonia, Viral - virology
Pneumonitis
Treatment Outcome
Ventilation
Ventilators
Viral Load
Viruses
Zanamivir
Zanamivir - therapeutic use
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Description
Summary:In view of high volume gastric aspirates, we used nebulised zanamivir. Since her infl amed, atelectatic lungs were probably im peding adequate drug absorption, and clinical improve ment was not forth coming, we used intravenous (un licensed) zanamivir.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(09)61528-2