Antiviral efficacy of qust (Saussurea lappa) and afsanteen (Artemisia absinthium) for chronic Hepatitis B: A prospective single-arm pilot clinical trial

Background/Aim: Chronic hepatitis B (CHB) is a major health concern in terms of high prevalence, as well as restricted and costly health-care resources in India. The objective was to evaluate the antiviral effect of herbal drugs, Saussurea lappa and Artemisia absinthium against hepatitis B virus (HB...

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Bibliographic Details
Published in:Pharmacognosy research 2018-07, Vol.10 (3), p.282-290
Main Authors: Ansari, Shabnam, Siddiqui, Mohammad, Malhotra, Sharad, Maaz, Mohammad
Format: Article
Language:English
Subjects:
Clinical trials
Councils
Drug dosages
Drug resistance
Health education
Hepatitis
Hepatitis B
Hypertension
Medicine
Patients
Publishing
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Summary:Background/Aim: Chronic hepatitis B (CHB) is a major health concern in terms of high prevalence, as well as restricted and costly health-care resources in India. The objective was to evaluate the antiviral effect of herbal drugs, Saussurea lappa and Artemisia absinthium against hepatitis B virus (HBV) in the management of CHB and to collect data to warrant further clinical trials. Materials and Methods: In an open prospective single-arm study, we assigned thirty patients with HBeAg-negative or positive CHB to receive decoction of S. lappa, 15 mL in the morning, and decoction of A. absinthium, 15 mL in the evening once daily empty stomach for 12 weeks. Test drug was evaluated for its efficacy in loss of HBsAg and HBeAg, plasma HBV DNA level of
ISSN:0974-8490
0976-4836
0974-8490
DOI:10.4103/pr.pr_157_17