Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey

Erionite present in stones used to build the villages of Karain and Tuzköy, Turkey, mined from nearby caves, is purported to cause mesothelioma in half of the villagers. We constructed genetic epidemiology maps to test whether some villagers were genetically predisposed to mesothelioma. Analysis of...

Full description

Saved in:
Bibliographic Details
Published in:The Lancet (British edition) 2001-02, Vol.357 (9254), p.444-445
Main Authors: Roushdy-Hammady, Iman, Siegel, Jennifer, Emri, Salih, Testa, Joseph R, Carbone, Michele
Format: Article
Language:English
Subjects:
Adult
Aged
Asbestos
Biological and medical sciences
Caves
Chromosome Aberrations - genetics
Chromosome Disorders
Epidemiology
Families & family life
Female
Founder Effect
Gene mapping
Genes, Dominant - genetics
Genetic Predisposition to Disease - genetics
Genetics
Genetics, Population
Humans
Inbreeding
Industrialized nations
Male
Manufacturing
Medical disorders
Medical sciences
Mesothelioma
Mesothelioma - genetics
Mesothelioma - mortality
Middle Aged
Mining
Pedigree
Pleural Neoplasms - genetics
Pleural Neoplasms - mortality
Population
Risk factors
Stone
Survival Rate
Tropical medicine
Tumors
Turkey
Villages
Women
Zeolites - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Erionite present in stones used to build the villages of Karain and Tuzköy, Turkey, mined from nearby caves, is purported to cause mesothelioma in half of the villagers. We constructed genetic epidemiology maps to test whether some villagers were genetically predisposed to mesothelioma. Analysis of a six-generation extended pedigree of 526 individuals showed that mesothelioma was genetically transmitted, probably in an autosomal dominant way. This finding should lead to preventive strategies to lower the incidence of mesothelioma in future generations, and close monitoring of high-risk individuals might allow early detection and cure.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(00)04013-7