Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates

Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4‐dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyr...

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Bibliographic Details
Published in:Journal of food science 2018-07, Vol.83 (7), p.1781-1791
Main Authors: Imran, Muhammad, Nadeem, Muhammad, Gilani, Syed Amir, Khan, Shaista, Sajid, Muhammad Wasim, Amir, Rai Muhammad
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
anticancer perspectives
Antineoplastic Agents
Bioactive compounds
Brain
Carcinogenesis
Carcinogens
Cardiovascular diseases
Cell growth
Cell migration
Cell Movement - drug effects
Cell proliferation
Cell Proliferation - drug effects
Cervix
Colon
Coronary artery disease
Coronary Disease - drug therapy
Deoxyribonucleic acid
DNA
DNA damage
DNA Damage - drug effects
Ethanol
Gene expression
Heart diseases
Humans
hydroxytyrosol
Iridoids - pharmacology
Iridoids - therapeutic use
Lungs
metabolism
Metastases
Neoplasm Invasiveness - prevention & control
Neoplasms - drug therapy
Neoplasms - prevention & control
Neovascularization, Pathologic - prevention & control
Oils & fats
Olea
Oleuropein
Olive oil
Olive Oil - chemistry
olive oil phenols
Olives
Phenols
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - pharmacology
Phenylethyl Alcohol - therapeutic use
Proteins
Pyrans
Skin
Thyroid
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Summary:Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4‐dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyrosol in olive oil. Both plays a significant role in the reduction of coronary heart diseases and a certain type of cancers. Both olive oil phenols have an effective role counter to cell proliferation, cell growth, migration, invasion, and angiogenesis. They down regulate the expression of BCL‐2 and COX‐2 proteins, and reduced DNA damage. Hydroxytyrosol and oleuropein inhibited the multiple stages in colon carcinogenesis; initiation, promotion, and metastasis. They also provide protection against various human cancers including colorectal, skin, breast, thyroid, digestive, lung, brain, blood, and cervical. This review article discusses the anticancer perspectives and mechanisms of oleuropein and hydroxytyrosol in cell cultures and animal and human studies.
ISSN:0022-1147
1750-3841
DOI:10.1111/1750-3841.14198