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Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates
Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4‐dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyr...
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| Published in: | Journal of food science 2018-07, Vol.83 (7), p.1781-1791 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c4138-50863935f3d4776bd9ec244773a5bb535d1da588405a6651b9074d0e8945fb243 |
| container_end_page | 1791 |
| container_issue | 7 |
| container_start_page | 1781 |
| container_title | Journal of food science |
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| creator | Imran, Muhammad Nadeem, Muhammad Gilani, Syed Amir Khan, Shaista Sajid, Muhammad Wasim Amir, Rai Muhammad |
| description | Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4‐dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyrosol in olive oil. Both plays a significant role in the reduction of coronary heart diseases and a certain type of cancers. Both olive oil phenols have an effective role counter to cell proliferation, cell growth, migration, invasion, and angiogenesis. They down regulate the expression of BCL‐2 and COX‐2 proteins, and reduced DNA damage. Hydroxytyrosol and oleuropein inhibited the multiple stages in colon carcinogenesis; initiation, promotion, and metastasis. They also provide protection against various human cancers including colorectal, skin, breast, thyroid, digestive, lung, brain, blood, and cervical. This review article discusses the anticancer perspectives and mechanisms of oleuropein and hydroxytyrosol in cell cultures and animal and human studies. |
| doi_str_mv | 10.1111/1750-3841.14198 |
| format | article |
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Oleuropein is the ester of elenolic acid and 3,4‐dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyrosol in olive oil. Both plays a significant role in the reduction of coronary heart diseases and a certain type of cancers. Both olive oil phenols have an effective role counter to cell proliferation, cell growth, migration, invasion, and angiogenesis. They down regulate the expression of BCL‐2 and COX‐2 proteins, and reduced DNA damage. Hydroxytyrosol and oleuropein inhibited the multiple stages in colon carcinogenesis; initiation, promotion, and metastasis. They also provide protection against various human cancers including colorectal, skin, breast, thyroid, digestive, lung, brain, blood, and cervical. 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This review article discusses the anticancer perspectives and mechanisms of oleuropein and hydroxytyrosol in cell cultures and animal and human studies.</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>anticancer perspectives</subject><subject>Antineoplastic Agents</subject><subject>Bioactive compounds</subject><subject>Brain</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Cardiovascular diseases</subject><subject>Cell growth</subject><subject>Cell migration</subject><subject>Cell Movement - drug effects</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cervix</subject><subject>Colon</subject><subject>Coronary artery disease</subject><subject>Coronary Disease - drug therapy</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA Damage - drug effects</subject><subject>Ethanol</subject><subject>Gene expression</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>hydroxytyrosol</subject><subject>Iridoids - pharmacology</subject><subject>Iridoids - therapeutic use</subject><subject>Lungs</subject><subject>metabolism</subject><subject>Metastases</subject><subject>Neoplasm Invasiveness - prevention & control</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - prevention & control</subject><subject>Neovascularization, Pathologic - prevention & control</subject><subject>Oils & fats</subject><subject>Olea</subject><subject>Oleuropein</subject><subject>Olive oil</subject><subject>Olive Oil - chemistry</subject><subject>olive oil phenols</subject><subject>Olives</subject><subject>Phenols</subject><subject>Phenylethyl Alcohol - analogs & derivatives</subject><subject>Phenylethyl Alcohol - pharmacology</subject><subject>Phenylethyl Alcohol - therapeutic use</subject><subject>Proteins</subject><subject>Pyrans</subject><subject>Skin</subject><subject>Thyroid</subject><issn>0022-1147</issn><issn>1750-3841</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkD1PwzAQhi0EglKY2ZAl5hQ7thObDQGFoqIivlYriS9SUBoH2wHy70kosHLLfei9904PQkeUzOgQpzQVJGKS0xnlVMktNPmbbKMJIXEcUcrTPbTv_SsZe5bsor1YqVimMpmgl_MmVKFbW4fvwfkWilC9g8e2xKsaOmdbqBqcNQYvgsd3ELLc1lUAfNMbZz_70DvrbX2GH6CAJuDn1mQB_AHaKbPaw-FPnqLn-dXTxU20XF0vLs6XUcEpk5EgMmGKiZIZnqZJbhQUMR9Klok8F0wYajIhJSciSxJBc0VSbghIxUWZx5xN0cnGt3X2rQMf9KvtXDOc1DFJUqnYeGGKTjeqYnjWOyh166p15npNiR456pGaHqnpb47DxvGPb5evwfzpf8ENgmQj-Khq6P_z07fzy8eN8xfNEXwX</recordid><startdate>201807</startdate><enddate>201807</enddate><creator>Imran, Muhammad</creator><creator>Nadeem, Muhammad</creator><creator>Gilani, Syed Amir</creator><creator>Khan, Shaista</creator><creator>Sajid, Muhammad Wasim</creator><creator>Amir, Rai Muhammad</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0002-0192-0971</orcidid></search><sort><creationdate>201807</creationdate><title>Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates</title><author>Imran, Muhammad ; Nadeem, Muhammad ; Gilani, Syed Amir ; Khan, Shaista ; Sajid, Muhammad Wasim ; Amir, Rai Muhammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4138-50863935f3d4776bd9ec244773a5bb535d1da588405a6651b9074d0e8945fb243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>anticancer perspectives</topic><topic>Antineoplastic Agents</topic><topic>Bioactive compounds</topic><topic>Brain</topic><topic>Carcinogenesis</topic><topic>Carcinogens</topic><topic>Cardiovascular diseases</topic><topic>Cell growth</topic><topic>Cell migration</topic><topic>Cell Movement - drug effects</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Cervix</topic><topic>Colon</topic><topic>Coronary artery disease</topic><topic>Coronary Disease - drug therapy</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA damage</topic><topic>DNA Damage - drug effects</topic><topic>Ethanol</topic><topic>Gene expression</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>hydroxytyrosol</topic><topic>Iridoids - pharmacology</topic><topic>Iridoids - therapeutic use</topic><topic>Lungs</topic><topic>metabolism</topic><topic>Metastases</topic><topic>Neoplasm Invasiveness - prevention & control</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - prevention & control</topic><topic>Neovascularization, Pathologic - prevention & control</topic><topic>Oils & fats</topic><topic>Olea</topic><topic>Oleuropein</topic><topic>Olive oil</topic><topic>Olive Oil - chemistry</topic><topic>olive oil phenols</topic><topic>Olives</topic><topic>Phenols</topic><topic>Phenylethyl Alcohol - analogs & derivatives</topic><topic>Phenylethyl Alcohol - pharmacology</topic><topic>Phenylethyl Alcohol - therapeutic use</topic><topic>Proteins</topic><topic>Pyrans</topic><topic>Skin</topic><topic>Thyroid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Imran, Muhammad</creatorcontrib><creatorcontrib>Nadeem, Muhammad</creatorcontrib><creatorcontrib>Gilani, Syed Amir</creatorcontrib><creatorcontrib>Khan, Shaista</creatorcontrib><creatorcontrib>Sajid, Muhammad Wasim</creatorcontrib><creatorcontrib>Amir, Rai Muhammad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Journal of food science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Imran, Muhammad</au><au>Nadeem, Muhammad</au><au>Gilani, Syed Amir</au><au>Khan, Shaista</au><au>Sajid, Muhammad Wasim</au><au>Amir, Rai Muhammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates</atitle><jtitle>Journal of food science</jtitle><addtitle>J Food Sci</addtitle><date>2018-07</date><risdate>2018</risdate><volume>83</volume><issue>7</issue><spage>1781</spage><epage>1791</epage><pages>1781-1791</pages><issn>0022-1147</issn><eissn>1750-3841</eissn><abstract>Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. 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| subjects | Angiogenesis Animals anticancer perspectives Antineoplastic Agents Bioactive compounds Brain Carcinogenesis Carcinogens Cardiovascular diseases Cell growth Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Cervix Colon Coronary artery disease Coronary Disease - drug therapy Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects Ethanol Gene expression Heart diseases Humans hydroxytyrosol Iridoids - pharmacology Iridoids - therapeutic use Lungs metabolism Metastases Neoplasm Invasiveness - prevention & control Neoplasms - drug therapy Neoplasms - prevention & control Neovascularization, Pathologic - prevention & control Oils & fats Olea Oleuropein Olive oil Olive Oil - chemistry olive oil phenols Olives Phenols Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - pharmacology Phenylethyl Alcohol - therapeutic use Proteins Pyrans Skin Thyroid |
| title | Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates |
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