Microwave‐assisted Synthesis of Hybrid Heterocyclics as Biological Potent Molecules

A series of novel 5‐((1H‐benzo[d]imidazol‐2‐yl)methyl)‐2‐((3aR,5S,6S,6aR)‐2,2‐dimethyl‐6‐((1‐phenyl‐1H‐1,2,3‐triazol‐4‐yl)methoxy)tetrahydrofuro[2,3‐d][1,3]dioxol‐5‐yl)‐3‐phenylthiazolidin‐4‐ones 9a–n has been synthesized from triazole‐linked thiazolidinone derivatives 8a–g with o‐phenylenediamine a...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2018-07, Vol.55 (7), p.1564-1573
Main Authors: Srinivas, A., Sunitha, M., Vasumathi Reddy, K., Karthik, P., Rajesh Kumar, G.
Format: Article
Language:English
Subjects:
Bacteria
Chemical synthesis
E coli
Iridium
Molecular chains
NMR
Nuclear magnetic resonance
Phenylenediamine
Salmonella
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Summary:A series of novel 5‐((1H‐benzo[d]imidazol‐2‐yl)methyl)‐2‐((3aR,5S,6S,6aR)‐2,2‐dimethyl‐6‐((1‐phenyl‐1H‐1,2,3‐triazol‐4‐yl)methoxy)tetrahydrofuro[2,3‐d][1,3]dioxol‐5‐yl)‐3‐phenylthiazolidin‐4‐ones 9a–n has been synthesized from triazole‐linked thiazolidinone derivatives 8a–g with o‐phenylenediamine and characterized by IR, NMR, MS, and elemental analyses. Further, these compounds were screened for their antibacterial activity against Gram‐positive bacteria, namely, Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 6538p), and Micrococcus luteus (IFC 12708), and Gram‐negative bacteria, namely, Proteus vulgaris (ATCC 3851), Salmonella typhimurium (ATCC 14028), and Escherichia coli (ATCC 25922). Among the screened compounds, compounds 9b, 9d, 9h, and 9i are highly active against almost all selected bacterial strains; the remaining compounds showed moderate to good activity and emerged as potential molecules for further development.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3187