A Facile Method with Low Hydrothermal Temperature to Synthesize TiO2 as Controlled Release Drug Delivery

• Published in: Physica status solidi. A, Applications and materials science Applications and materials science, 2018-07, Vol.215 (13), p.n/a
• Main Authors: Liu, Di, Lin, Zi‐ting, Tang, Hai‐xia, Deng, Shi‐ting, Bi, Yong‐guang
• Format: Article
• Language: English
• Subjects: Controlled release; Correlation coefficients; Drug delivery systems; drug loading; Emission analysis; Encapsulation; Energy conservation; Field emission microscopy; homogeneous precipitation; hydrothermal; Morphology; release kinetics; Scanning electron microscopy; Spectrum analysis; Sulfuric acid; Sustained release; Titanium; Titanium dioxide; X-ray diffraction
• ISSN: 1862-6300; 1862-6319
• DOI: 10.1002/pssa.201800068

Titania is obtained by taking titanium oxysulfate sulfuric acid complex hydrate as Ti source with a simple, energy saving process. The effect of hydrothermal time and temperature on morphology is investigated. The particle size and morphology are analyzed by X‐Ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive X‐ray spectroscopy (EDS), and Raman spectroscopy. Additionally, the effect of tetracycline/TiO2 ratio on drug loading capacity and encapsulation rate are studied. Zero‐order kinetics, first‐order kinetic, and Higuichi kinetic models are employed to investigate the drug release kinetics. The morphology of as‐prepared TiO2 treated with hydrothermal temperature of 120 °C for 0.5 h is most regular, presents microsphere shape which is composed of small particles with size of 19.36 nm and shows high drug loading capacity (32.25 ± 0.46%) and high encapsulation rate (47.63 ± 1.41%) due to the large specific surface area of 91.0629 m2 g−1, and it fits well with Higuichi equation with the correlation coefficients of 0.96981, illustrating that TiO2 has sustained release function. Therefore, this paper provides a convenient route to prepare TiO2 with good performance. Titanium dioxide is synthesized by hydrothermal assisted homogeneous precipitation method, the hydrothermal temperature and time are investigated to achieve low energy and environmental protection, the obtained powder showed high drug loading capacity due to its large specific surface area (91.0629 m2 g−1), and its release kinetic shows that it fits well with Higuichi equation, indicating that it has excellent release performance.