An azobenzene-based heteromeric prodrug for hypoxia-activated chemotherapy by regulating subcellular localization

An azobenzene-based heteromeric prodrug (hNDP) was prepared for targeted chemotherapy against hypoxic tumor. hNDP could divert the parent drug from nucleus to cytoplasm with lower toxicity, while the azoreduction of hNDP in hypoxia would activate the drug with a robust anti-tumor effect by initiatin...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (57), p.7983-7986
Main Authors: Li, Shiying, Jiang, Xueyan, Zheng, Rongrong, Zuo, Shengjia, Zhao, Linping, Fan, Guiling, Fan, Jinghao, Liao, Yonghua, Yu, Xiyong, Cheng, Hong
Format: Article
Language:English
Subjects:
Anticancer properties
Apoptosis
Cascades
Chemotherapy
Cytoplasm
Hypoxia
Toxicity
Tumors
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Summary:An azobenzene-based heteromeric prodrug (hNDP) was prepared for targeted chemotherapy against hypoxic tumor. hNDP could divert the parent drug from nucleus to cytoplasm with lower toxicity, while the azoreduction of hNDP in hypoxia would activate the drug with a robust anti-tumor effect by initiating the apoptosis-related biochemical cascades.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc03430c