A Novel Amorphous Delivery System to the Skin for Poorly Soluble Actives

At 1/500th the concentration of rutin dissolved from nanocrystals, a two-fold increase in sun protection factor (SPF) was observed in a human study with irradiated volunteers (4). According to the EU cosmetic regulation (6), for example, nanoparticulate ingredients must be declared, such as the case...

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Bibliographic Details
Published in:Pharmaceutical technology Europe 2018-06, Vol.30 (6), p.19-21
Main Authors: Müller, Rainer H, Herziger, Birthe, Monsuur, Fred, Pyo, Sung Min
Format: Article
Language:English
Subjects:
Alcohol
Cosmetics
Crystallization
Nanocrystals
Nanoparticles
Polyethylene glycol
Regulation
Skin
Solvents
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Summary:At 1/500th the concentration of rutin dissolved from nanocrystals, a two-fold increase in sun protection factor (SPF) was observed in a human study with irradiated volunteers (4). According to the EU cosmetic regulation (6), for example, nanoparticulate ingredients must be declared, such as the case of titanium dioxide used in sunscreens. Because smartPearls are microparticles, no "nano" declaration is necessary for the final product. With the co-solvents approach, crystallization can also happen when the solvent penetrates into the skin faster than the active itself. smartPearls combine the solubility increases (ACs) from both the amorphous state and the nanodimension, further increasing the saturation solubility and providing an efficient dermal delivery system.
ISSN:1753-7967