Multicomponent reactions in the synthesis of dihydropyrimidine-containing podands having tuberculostatic activity

Dihydropyrimidinethione podands, as well as podands containing 2-thienyl substituents have been synthesized via the multicomponent Biginelli reaction. Tuberculostatic activity of the novel podands was shown to depend on the polyether unit length. In particular, activity of dihydropyrimidinethione po...

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Bibliographic Details
Published in:Russian chemical bulletin 2018-04, Vol.67 (4), p.743-746
Main Authors: Fedorova, O. V., Filatova, E. S., Titova, Yu. A., Kravchenko, M. A., Medvinskiy, I. D., Rusinov, G. L., Charushin, V. N.
Format: Article
Language:English
Subjects:
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Inorganic Chemistry
Organic Chemistry
Tuberculosis
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Summary:Dihydropyrimidinethione podands, as well as podands containing 2-thienyl substituents have been synthesized via the multicomponent Biginelli reaction. Tuberculostatic activity of the novel podands was shown to depend on the polyether unit length. In particular, activity of dihydropyrimidinethione podands against laboratory strains of Mycobacterium tuberculosis , H 37 Rv, M. avium , M. terrae , and the clinical strain of multi-drug resistant M. tuberculosis (MDR), increases with a shortening of the polyether unit length.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-018-2131-6