Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection

In two of 15 patients coinfected with HIV and hepatitis C virus who received interferon-α plus ribavirin in addition to HAART, we observed multiorgan dysfunction and lactic acidaemia. As ribavirin is a nucleoside analogue, an increased risk of mitochondrial toxicity can be induced in HIV-infected pa...

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Bibliographic Details
Published in:The Lancet (British edition) 2001-01, Vol.357 (9252), p.280-281
Main Authors: Lafeuillade, Alain, Hittinger, Gilles, Chadapaud, Stephane
Format: Article
Language:English
Subjects:
Anemia
Antiretroviral drugs
Antiretroviral Therapy, Highly Active
Antiviral Agents - adverse effects
Biological and medical sciences
Computed tomography
Deoxyribonucleic acid
DNA
Drug therapy
Drug Therapy, Combination
Drug toxicity and drugs side effects treatment
Hepatitis
Hepatitis C
Hepatitis C - complications
Hepatitis C - drug therapy
Highly active antiretroviral therapy
HIV
HIV Infections - complications
HIV Infections - drug therapy
Human immunodeficiency virus
Humans
Infections
Interferon
Interferon-alpha - adverse effects
Interferon-alpha - therapeutic use
Liver
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Mitochondria
Mitochondrial DNA
Mitochondrial Myopathies - chemically induced
Nucleoside analogs
Nucleosides
Pancreatitis
Patients
Pharmacology. Drug treatments
Ribavirin
Ribavirin - adverse effects
Toxicity
Viruses
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Summary:In two of 15 patients coinfected with HIV and hepatitis C virus who received interferon-α plus ribavirin in addition to HAART, we observed multiorgan dysfunction and lactic acidaemia. As ribavirin is a nucleoside analogue, an increased risk of mitochondrial toxicity can be induced in HIV-infected patients already treated with nucleoside analogues, leading to clinical deterioration in some cases.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(00)03618-7