Investigation of pH-Sensitive Swelling and Curcumin Release Behavior of Chitglc Hydrogel

Hydrogels are in use for encapsulation of curcumin for possible use in wound healing. Encapsulation helps in targeted delivery and enhanced activity of curcumin. We report here a pH sensitive hydrogel developed from chitosan. The hydrogel was prepared by reaction of chitosan and d -glucose, facilita...

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Bibliographic Details
Published in:Journal of polymers and the environment 2018-10, Vol.26 (10), p.4034-4045
Main Authors: Deka, Chayanika, Deka, Deepanwita, Bora, Montu Moni, Jha, Dhruva Kumar, Kakati, Dilip Kumar
Format: Article
Language:English
Subjects:
Aerogenes
Antibacterial activity
Chemistry
Chemistry and Materials Science
Chitosan
Controlled release
Curcumin
Encapsulation
Environmental Chemistry
Environmental Engineering/Biotechnology
Glucose
Hydrogels
Industrial Chemistry/Chemical Engineering
Materials Science
Original Paper
pH effects
Polymer Sciences
Reducing agents
Sustained release
Wound healing
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Summary:Hydrogels are in use for encapsulation of curcumin for possible use in wound healing. Encapsulation helps in targeted delivery and enhanced activity of curcumin. We report here a pH sensitive hydrogel developed from chitosan. The hydrogel was prepared by reaction of chitosan and d -glucose, facilitated by the reducing agent Na-cyanoborohydride. The maximum yield of the hydrogel was obtained at pH 4.5 with the amount of chitosan, d -glucose and Na-cyanoborohydride as 0.3, 2.0 and 2.0 g respectively. A maximum curcumin loading efficiency of 74% was observed with curcumin amount in the feed at 0.15 g. The release study revealed a sustained release pattern over a period of 80 h with an initial burst release. Curcumin loaded hydrogel showed mild antibacterial activity against Proteus mirabilis and Enterobacter aerogenes .
ISSN:1566-2543
1572-8919
DOI:10.1007/s10924-018-1272-x