Study of a Prototype VP-PET Imaging System Based on highly Pixelated CdZnTe Detectors

We are investigating a prototype virtual pinhole positron emission tomography (VP-PET) system for small animal imaging applications. The PET detector modules were made up of 1.3 mm lutetium-yttrium oxyorthosilicate (LYSO) arrays, and the insert detectors consists of 0.6 mm pixelated Cadmium Zinc Tel...

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Bibliographic Details
Published in:arXiv.org 2018-01
Main Authors: Zheng-Qian, Ye, Ying-Guo, Li, Tian-Quan, Wang, Ya-Ming, Fan, Yong-Zhi, Yin, Xi-Meng, Chen
Format: Article
Language:English
Subjects:
Algorithms
Cadmium zinc tellurides
Computer simulation
Detectors
Emission analysis
Energy resolution
Image reconstruction
Lutetium
Medical imaging
Monte Carlo simulation
Pinholes
Point sources
Positron emission
Sensors
Tomography
Yttrium
Zinc tellurides
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Summary:We are investigating a prototype virtual pinhole positron emission tomography (VP-PET) system for small animal imaging applications. The PET detector modules were made up of 1.3 mm lutetium-yttrium oxyorthosilicate (LYSO) arrays, and the insert detectors consists of 0.6 mm pixelated Cadmium Zinc Telluride (CdZnTe). To validate the imaging experiment, we conducted a Monte Carlo simulation for the VP-PET system in Geant4 Application for Emission Tomography (GATE). For a point source of Na-22 with 0.5 mm diameter, the filtered back-projection (FBP) algorithm reconstructed PET image shows a resolution of 0.7 mm full-width-at-half-maximum (FWHM). The system sensitivity is 0.46 cps/kBq at the center of field view (CFOV) of the PET system with a source activity of 0.925 MBq and an energy resolution of 350-650 keV. A rod source phantom and a Derenzo phantom with F-18 were also simulated to investigate the PET imaging capability. GATE simulation indicated that two point sources with 0.5 mm diameter 2 mm apart could be clearly separated using 0.6 mm pixelated CdZnTe detectors as insert devices in a VP-PET system.
ISSN:2331-8422