Evaluation of hematological and biochemical parameters of pesticide retailers following occupational exposure to a mixture of pesticides

Aims: This study was undertaken to ascertain whether light occupational exposure to pesticides by retailers might be associated with any liver, kidney, nervous system dysfunction or hematological abnormalities. Main methods: In this cross-sectional study, 70 male pesticide retailers (cases) and 64 m...

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Bibliographic Details
Published in:Life sciences (1973) 2018-06, Vol.202, p.182-187
Main Authors: Neghab, Masoud, Jalilian, Hamed, Taheri, Shekoufeh, Tatar, Mohsen, Haji Zadeh, Zeynab
Format: Article
Language:English
Subjects:
Abnormalities
Blood levels
Contractors
Data analysis
Data processing
Erythrocytes
Exposure
Hematocrit
Hematology
Hematotoxicity
Hemoglobin
Hepatotoxicity
Human exposure
Liver
Liver diseases
Monocytes
Nephrotoxicity
Nervous system
Neurotoxicity
Occupational exposure
Occupational hazards
Occupational health
Parameters
Pesticide
Pesticides
Retailer
Statistical tests
Toxicity
Urine
Workers
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Summary:Aims: This study was undertaken to ascertain whether light occupational exposure to pesticides by retailers might be associated with any liver, kidney, nervous system dysfunction or hematological abnormalities. Main methods: In this cross-sectional study, 70 male pesticide retailers (cases) and 64 male subjects, randomly selected from the constructions workers of city council contractors, as the referent group, were investigated. Urine and blood samples were taken from all subjects for urine analysis, hematological and biochemical parameters. Data analysis was conducted through SPSS v.19 using t-test and chi-square test. Key findings: The results of urine analysis showed that the frequency of abnormal urine tests was significantly higher in cases than in referent individuals. Similarly, the results of CBC showed that the mean values of monocyte, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin and platelet distribution width were significantly lower, and mean corpuscular hemoglobin concentration and red blood cell distribution width were significantly higher in retailers. No significant differences were found for other parameters. Significance: These findings indicate that an association exists between exposure to pesticides by retailers and early subtle and sub-clinical changes in the urine tests and hematological parameters. Engineering measures are recommended to eliminate exposure to pesticides and to prevent its associated outcomes.
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2018.04.020