Method for identification of condition-associated public antigen receptor sequences

Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequence...

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Bibliographic Details
Published in:arXiv.org 2017-09
Main Authors: Pogorelyy, Mikhail V, Minervina, Anastasia A, Chudakov, Dmitriy M, Mamedov, Ilgar Z, Lebedev, Yury B, Mora, Thierry, Walczak, Aleksandra M
Format: Article
Language:English
Subjects:
Adaptive systems
Antigens
Immunoglobulins
Receptors
Sequences
T cell receptors
Online Access:Get full text
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Summary:Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously validated Cytomegalovirus and type 1 diabetes responsive receptors.
ISSN:2331-8422
DOI:10.48550/arxiv.1709.09703