The Yin and Yang of endothelium-derived vasodilator factors

Kadlec et al discuss the study conducted by Tanaka et al. addressing the gap in knowledge to expand their understanding of the pathogenesis of pulmonary hypertension (PH). The implications of this research are far reaching. First, this study advances the notion that nitric oxide (NO) and EHDFF/H2O2...

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Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2018-05, Vol.314 (5), p.H892
Main Authors: Kadlec, Andrew O, Gutterman, David D
Format: Article
Language:English
Subjects:
Bioavailability
Endothelium
Hydrogen peroxide
Hypertension
Microvasculature
Nitric oxide
Pathogenesis
Prostacyclin
Pulmonary hypertension
Target recognition
Vasodilators
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container_title American journal of physiology. Regulatory, integrative and comparative physiology
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creator Kadlec, Andrew O
Gutterman, David D
description Kadlec et al discuss the study conducted by Tanaka et al. addressing the gap in knowledge to expand their understanding of the pathogenesis of pulmonary hypertension (PH). The implications of this research are far reaching. First, this study advances the notion that nitric oxide (NO) and EHDFF/H2O2 can act as synergistic vasodilators in the microcirculation, in line with the recent findings from others. Second, that NO only plays a partial role, and prostacyclin does not participate at all, during microvascular dilation either before or after the onset of PH supports the call to identify new targets. Third, the data suggest that simply increasing NO bioavailability.
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source American Physiological Society Journals
subjects Bioavailability
Endothelium
Hydrogen peroxide
Hypertension
Microvasculature
Nitric oxide
Pathogenesis
Prostacyclin
Pulmonary hypertension
Target recognition
Vasodilators
title The Yin and Yang of endothelium-derived vasodilator factors
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