Aminomethylation of Thiourea with Formaldehyde and Cyclic Amines

Three-component condensation of thiourea with equimolar amounts of formaldehyde and morpholine afforded N -(morpholin-4-ylmethyl) derivative, whereas analogous reaction with 2 equiv of formaldehyde and amine gave symmetrical N , N ′-bis(morpholin-4-ylmethyl)thiourea. In the condensation of thiourea...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2018-06, Vol.54 (6), p.878-885
Main Authors: Martinovich, Yu. A., Ramsh, S. M., Hamoud, F., Fundamenskii, V. S., Gurzhii, V. V., Zakharov, V. I., Khrabrova, E. S.
Format: Article
Language:English
Subjects:
Amines
Chemistry
Chemistry and Materials Science
Condensation
Formaldehyde
Morpholine
Organic Chemistry
Piperidine
Thioureas
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Summary:Three-component condensation of thiourea with equimolar amounts of formaldehyde and morpholine afforded N -(morpholin-4-ylmethyl) derivative, whereas analogous reaction with 2 equiv of formaldehyde and amine gave symmetrical N , N ′-bis(morpholin-4-ylmethyl)thiourea. In the condensation of thiourea with piperidine and formaldehyde, only symmetrical N,N ′-bis(piperidin-1-ylmethyl)thiourea was isolated, regardless of the reactant ratio.
ISSN:1070-4280
1608-3393
DOI:10.1134/S107042801806009X