Platelet Thromboxane A^sub 2^ Secretion in Patients With Major Depression Responsive to Electroconvulsive Therapy

To determine a) whether clinical response to electroconvulsive therapy (ECT) is associated with decreased platelet activation in patients with major depressive disorder (MDD) and b) if any medical/demographic characteristics predict response to ECT or changes in platelet activation. Increased platel...

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Bibliographic Details
Published in:Psychosomatic medicine 2008-04, Vol.70 (3), p.319
Main Authors: Bruce, Erica C, Guo, Ying, Lawson, Kathryn C, Manatunga, Amita K, Auyeung, S Freda, McDonald, William M, Rushing, Natasha, Brown, Angelo R, Gilles, Natalie, Emery, Milburn, Bonsall, Robert, Porquez, Jocelyn, Stowe, Zachary, Nemeroff, Charles B, Musselman, Dominique L
Format: Article
Language:English
Subjects:
Cardiovascular disease
Electroconvulsive therapy
Hypertension
Regression analysis
Risk factors
Studies
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Summary:To determine a) whether clinical response to electroconvulsive therapy (ECT) is associated with decreased platelet activation in patients with major depressive disorder (MDD) and b) if any medical/demographic characteristics predict response to ECT or changes in platelet activation. Increased platelet activation may underlie the increased risk of coronary artery disease (CAD) in patients with MDD. Before their first and sixth ECT treatments, study patients (n = 44) completed the Beck Depression Inventory (BDI) to assess the severity of depressive symptoms. Activity of the platelet thromboxane (TBX) A... pathway was assessed by measuring the morning spot urinary concentrations of 11-dehydroxy-thromboxane B... (11-D-TBX B...), a major metabolite of platelet-derived TBX A... Multivariate logistic regression analyses revealed that improvement on the BDI was significantly more likely in patients without a history of hypertension (p = .02) and in patients who were prescribed a greater number of "platelet-altering" medications (p = .03). During a course of ECT, a decrease in urinary 11-D-TBX B2 was significantly more likely to occur in ECT nonresponders (p = .01) and younger patients (p = .02). Clinical response to ECT coadministered may not be associated with decreases in platelet-derived TBX. Future studies will confirm which somatic "antidepression" treatments offer optimal thrombovascular benefits for depressed patients with multiple risk factors for, or clinically evident, cerebral disease or CAD. (ProQuest: ... denotes formulae/symbols omitted.)
ISSN:0033-3174
1534-7796