Genome-wide association study of T-wave morphology

Introduction: T wave morphology has been shown to contain different information regarding cardiac ion currents compared to the classical QT interval. Block of the HERG potassium current, IKr, gives characteristic T-wave features like flattening, skewing of the T-wave often with visible humps. Morpho...

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Bibliographic Details
Published in:Journal of electrocardiology 2017-11, Vol.50 (6), p.860-860
Main Authors: Graff, C., Grarup, N., Hansen, T., Kanters, J.K., Linneberg, A., Nielsen, J., Olesen, M.S.
Format: Article
Language:English
Subjects:
Genetics
Genomes
Morphology
Potassium
Online Access:Get full text
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Summary:Introduction: T wave morphology has been shown to contain different information regarding cardiac ion currents compared to the classical QT interval. Block of the HERG potassium current, IKr, gives characteristic T-wave features like flattening, skewing of the T-wave often with visible humps. Morphology Combination Score (MCS) has been developed as a better HERG block indicator then the QT interval. The aim of the study was to investigate the influence of normal genetic variation on MCS.
ISSN:0022-0736
1532-8430
DOI:10.1016/j.jelectrocard.2017.08.048