A computational model describing the interplay of basal ganglia and subcortical background oscillations during working memory processes

Working memory is responsible for the temporary manipulation and storage of information to support reasoning, learning and comprehension in the human brain. Background oscillations from subcortical structures may drive a gating or switching mechanism during working memory computations, and different...

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Bibliographic Details
Published in:arXiv.org 2016-01
Main Authors: Çelikok, Utku, Navarro-López, Eva M, Neslihan S \c{S}engör
Format: Article
Language:English
Subjects:
Brain
Computation
Dopamine
Frequencies
Ganglia
Information storage
Memory tasks
Oscillations
Switching
Online Access:Get full text
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Summary:Working memory is responsible for the temporary manipulation and storage of information to support reasoning, learning and comprehension in the human brain. Background oscillations from subcortical structures may drive a gating or switching mechanism during working memory computations, and different frequency bands may be associated with different processes while working memory tasks are performed. There are three well-known relationships between working memory processes and specific frequency bands of subcortical oscillations, namely: the storage of new information which correlates positively with beta/gamma-frequency band oscillations, the maintenance of information while ignoring irrelevant stimulation which is directly linked to theta-frequency band oscillations, and the clearance of memory which is associated with alpha-frequency band oscillations. Although these relationships between working memory processes and subcortical background oscillations have been observed, a full explanation of these phenomena is still needed. This paper will aid understanding of the working memory's operation and phase switching by proposing a novel and biophysical realistic mathematical-computational framework which unifies the generation of subcortical background oscillations, the role of basal ganglia-thalamo-cortical circuits and the influence of dopamine in the selection of working memory operations and phases: this has never been attempted before.
ISSN:2331-8422