Blood‐Catalyzed RAFT Polymerization

The use of hemoglobin (Hb) contained within red blood cells to drive a controlled radical polymerization via a reversible addition‐fragmentation chain transfer (RAFT) process is reported for the first time. No pre‐treatment of the Hb or cells was required prior to their use as polymerization catalys...

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Bibliographic Details
Published in:Angewandte Chemie 2018-08, Vol.130 (32), p.10445-10449
Main Authors: Reyhani, Amin, Nothling, Mitchell D., Ranji‐Burachaloo, Hadi, McKenzie, Thomas G., Fu, Qiang, Tan, Shereen, Bryant, Gary, Qiao, Greg G.
Format: Article
Language:English
Subjects:
Addition polymerization
Catalysis
Catalysts
Chain transfer
Chemistry
Engineering
Erythrocytes
Hemoglobin
Hydrogen peroxide
Hämoglobin
Macromolecules
Microenvironments
Polymerisationen
Polymerization
RAFT
Reagents
Rote Blutkörperchen
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Summary:The use of hemoglobin (Hb) contained within red blood cells to drive a controlled radical polymerization via a reversible addition‐fragmentation chain transfer (RAFT) process is reported for the first time. No pre‐treatment of the Hb or cells was required prior to their use as polymerization catalysts, indicating the potential for synthetic engineering in complex biological microenvironments without the need for ex vivo techniques. Owing to the naturally occurring prevalence of the reagents employed in the catalytic system (Hb and hydrogen peroxide), this approach may facilitate the development of new strategies for in vivo cell engineering with synthetic macromolecules. Hämoglobin (Hb) in roten Blutkörperchen wurde für eine kontrollierte radikalische Polymerisation über einen RAFT‐Prozess genutzt. Ohne Vorbehandlung konnten Hb oder Zellen als Polymerisationskatalysatoren verwendet werden, was auf die Möglichkeit synthetischer Modifizierungen in komplexen biologischen Mikroumgebungen ohne Einsatz von Ex‐vivo‐Techniken hindeutet.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201802544