HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugs

Graphical abstract After exposure to HCV the majority of PWID develop chronic HCV infection that can lead to liver cirrhosis and hepatocellular carcinoma. A small subgroup of PWID is able to clear HCV infection before and after seroconversion. PWID with multiple Bw4 alleles are more likely to clear...

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Bibliographic Details
Published in:Journal of hepatology 2017-09, Vol.67 (3), p.462-470
Main Authors: Thöns, Christine, Senff, Tina, Hydes, Theresa J, Manser, Angela R, Heinemann, Falko M, Heinold, Andreas, Heilmann, Martin, Kim, Arthur Y, Uhrberg, Markus, Scherbaum, Norbert, Lauer, Georg M, Khakoo, Salim I, Timm, Jörg
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Copy number
Female
Flow cytometry
Gastroenterology and Hepatology
Gene Dosage
Genotype
Genotype & phenotype
Genotypes
HCV
Hepatitis
Hepatitis C
Hepatitis C - immunology
Histocompatibility antigen HLA
HLA-B Antigens - genetics
Humans
Immunoglobulin-like receptors
Injections
Killer cell immunoglobulin-like receptor
Killer cell immunoglobulin-like receptors
Killer Cells, Natural - immunology
KIR3DL1
Ligands
Logistic Models
Male
Middle Aged
Natural killer cells
NK cell
Potassium channels (inwardly-rectifying)
Receptor mechanisms
Receptors, KIR3DL1 - genetics
Receptors, KIR3DL1 - physiology
Ribonucleic acid
RNA
RNA, Viral - blood
Seroconversion
Substance Abuse, Intravenous - immunology
Substance Abuse, Intravenous - virology
Young Adult
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Description
Summary:Graphical abstract After exposure to HCV the majority of PWID develop chronic HCV infection that can lead to liver cirrhosis and hepatocellular carcinoma. A small subgroup of PWID is able to clear HCV infection before and after seroconversion. PWID with multiple Bw4 alleles are more likely to clear HCV prior to seroconversion than PWID with one or no Bw4 allele. In addition PWID that encode both KIR3DL1 and a Bw4 80(T) motif have higher chances of spontaneously clearing HCV after seroconversion.
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2017.03.040