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HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugs
Graphical abstract After exposure to HCV the majority of PWID develop chronic HCV infection that can lead to liver cirrhosis and hepatocellular carcinoma. A small subgroup of PWID is able to clear HCV infection before and after seroconversion. PWID with multiple Bw4 alleles are more likely to clear...
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| Published in: | Journal of hepatology 2017-09, Vol.67 (3), p.462-470 |
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| Main Authors: | , , , , , , , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c483t-7753f3d3907c1089ccda3c083afd7af9a32ec17ad571a0d9e000092fec422c9f3 |
| container_end_page | 470 |
| container_issue | 3 |
| container_start_page | 462 |
| container_title | Journal of hepatology |
| container_volume | 67 |
| creator | Thöns, Christine Senff, Tina Hydes, Theresa J Manser, Angela R Heinemann, Falko M Heinold, Andreas Heilmann, Martin Kim, Arthur Y Uhrberg, Markus Scherbaum, Norbert Lauer, Georg M Khakoo, Salim I Timm, Jörg |
| description | Graphical abstract After exposure to HCV the majority of PWID develop chronic HCV infection that can lead to liver cirrhosis and hepatocellular carcinoma. A small subgroup of PWID is able to clear HCV infection before and after seroconversion. PWID with multiple Bw4 alleles are more likely to clear HCV prior to seroconversion than PWID with one or no Bw4 allele. In addition PWID that encode both KIR3DL1 and a Bw4 80(T) motif have higher chances of spontaneously clearing HCV after seroconversion. |
| doi_str_mv | 10.1016/j.jhep.2017.03.040 |
| format | article |
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A small subgroup of PWID is able to clear HCV infection before and after seroconversion. PWID with multiple Bw4 alleles are more likely to clear HCV prior to seroconversion than PWID with one or no Bw4 allele. In addition PWID that encode both KIR3DL1 and a Bw4 80(T) motif have higher chances of spontaneously clearing HCV after seroconversion.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/j.jhep.2017.03.040</identifier><identifier>PMID: 28412292</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; Copy number ; Female ; Flow cytometry ; Gastroenterology and Hepatology ; Gene Dosage ; Genotype ; Genotype & phenotype ; Genotypes ; HCV ; Hepatitis ; Hepatitis C ; Hepatitis C - immunology ; Histocompatibility antigen HLA ; HLA-B Antigens - genetics ; Humans ; Immunoglobulin-like receptors ; Injections ; Killer cell immunoglobulin-like receptor ; Killer cell immunoglobulin-like receptors ; Killer Cells, Natural - immunology ; KIR3DL1 ; Ligands ; Logistic Models ; Male ; Middle Aged ; Natural killer cells ; NK cell ; Potassium channels (inwardly-rectifying) ; Receptor mechanisms ; Receptors, KIR3DL1 - genetics ; Receptors, KIR3DL1 - physiology ; Ribonucleic acid ; RNA ; RNA, Viral - blood ; Seroconversion ; Substance Abuse, Intravenous - immunology ; Substance Abuse, Intravenous - virology ; Young Adult</subject><ispartof>Journal of hepatology, 2017-09, Vol.67 (3), p.462-470</ispartof><rights>2017 European Association for the Study of the Liver</rights><rights>Copyright © 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. 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A small subgroup of PWID is able to clear HCV infection before and after seroconversion. PWID with multiple Bw4 alleles are more likely to clear HCV prior to seroconversion than PWID with one or no Bw4 allele. In addition PWID that encode both KIR3DL1 and a Bw4 80(T) motif have higher chances of spontaneously clearing HCV after seroconversion.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Copy number</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Gastroenterology and Hepatology</subject><subject>Gene Dosage</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>HCV</subject><subject>Hepatitis</subject><subject>Hepatitis C</subject><subject>Hepatitis C - immunology</subject><subject>Histocompatibility antigen HLA</subject><subject>HLA-B Antigens - genetics</subject><subject>Humans</subject><subject>Immunoglobulin-like receptors</subject><subject>Injections</subject><subject>Killer cell immunoglobulin-like receptor</subject><subject>Killer cell immunoglobulin-like receptors</subject><subject>Killer Cells, Natural - immunology</subject><subject>KIR3DL1</subject><subject>Ligands</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natural killer cells</subject><subject>NK cell</subject><subject>Potassium channels (inwardly-rectifying)</subject><subject>Receptor mechanisms</subject><subject>Receptors, KIR3DL1 - genetics</subject><subject>Receptors, KIR3DL1 - physiology</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Viral - blood</subject><subject>Seroconversion</subject><subject>Substance Abuse, Intravenous - immunology</subject><subject>Substance Abuse, Intravenous - virology</subject><subject>Young Adult</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9UsFu1DAQtRCILoUf4IAscYFDwtjOrhMJIZUtsBUrIUHharn2hHXI2sFOuupf8Mk42rYHDpzGnnnvjWbeEPKcQcmArd50ZbfDoeTAZAmihAoekAVbARSwqthDssiguqi5rE_Ik5Q6ABDQVI_JCa8rxnnDF-TPZntWvD9UtIZXl6-p9pbup350Q4_0rmTC4DDlsL9yHi09uHFHP198FedbRnVKwTg94jGdhuBH7TFMmdCjjtobpKGlm_UP6nyLZnTB5xcdMMxNDruQf13OUxunn-kpedTqPuGz23hKvn_8cLneFNsvny7WZ9vCVLUYCymXohVWNCANg7oxxmphoBa6tVK3jRYcDZPaLiXTYBvMw0PDc_-Kc9O04pS8POoOMfyeMI2qC1P0uaXiUAOXS1jKjOJHlIkhpYitGqLb63ijGKjZBNWp2QQ1m6BAqGxCJr24lZ6u9mjvKXdbz4C3RwDmAa8dRpWMw7wo62JehLLB_V__3T900zvvjO5_4Q2m-zmYSlyB-jafwXwFTArgTDDxF5Ctq78</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Thöns, Christine</creator><creator>Senff, Tina</creator><creator>Hydes, Theresa J</creator><creator>Manser, Angela R</creator><creator>Heinemann, Falko M</creator><creator>Heinold, Andreas</creator><creator>Heilmann, Martin</creator><creator>Kim, Arthur Y</creator><creator>Uhrberg, Markus</creator><creator>Scherbaum, Norbert</creator><creator>Lauer, Georg M</creator><creator>Khakoo, Salim I</creator><creator>Timm, Jörg</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0003-1578-8163</orcidid></search><sort><creationdate>20170901</creationdate><title>HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugs</title><author>Thöns, Christine ; Senff, Tina ; Hydes, Theresa J ; Manser, Angela R ; Heinemann, Falko M ; Heinold, Andreas ; Heilmann, Martin ; Kim, Arthur Y ; Uhrberg, Markus ; Scherbaum, Norbert ; Lauer, Georg M ; Khakoo, Salim I ; Timm, Jörg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-7753f3d3907c1089ccda3c083afd7af9a32ec17ad571a0d9e000092fec422c9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Copy number</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Gastroenterology and Hepatology</topic><topic>Gene Dosage</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>HCV</topic><topic>Hepatitis</topic><topic>Hepatitis C</topic><topic>Hepatitis C - immunology</topic><topic>Histocompatibility antigen HLA</topic><topic>HLA-B Antigens - genetics</topic><topic>Humans</topic><topic>Immunoglobulin-like receptors</topic><topic>Injections</topic><topic>Killer cell immunoglobulin-like receptor</topic><topic>Killer cell immunoglobulin-like receptors</topic><topic>Killer Cells, Natural - immunology</topic><topic>KIR3DL1</topic><topic>Ligands</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Natural killer cells</topic><topic>NK cell</topic><topic>Potassium channels (inwardly-rectifying)</topic><topic>Receptor mechanisms</topic><topic>Receptors, KIR3DL1 - genetics</topic><topic>Receptors, KIR3DL1 - physiology</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Viral - blood</topic><topic>Seroconversion</topic><topic>Substance Abuse, Intravenous - immunology</topic><topic>Substance Abuse, Intravenous - virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thöns, Christine</creatorcontrib><creatorcontrib>Senff, Tina</creatorcontrib><creatorcontrib>Hydes, Theresa J</creatorcontrib><creatorcontrib>Manser, Angela R</creatorcontrib><creatorcontrib>Heinemann, Falko M</creatorcontrib><creatorcontrib>Heinold, Andreas</creatorcontrib><creatorcontrib>Heilmann, Martin</creatorcontrib><creatorcontrib>Kim, Arthur Y</creatorcontrib><creatorcontrib>Uhrberg, Markus</creatorcontrib><creatorcontrib>Scherbaum, Norbert</creatorcontrib><creatorcontrib>Lauer, Georg M</creatorcontrib><creatorcontrib>Khakoo, Salim I</creatorcontrib><creatorcontrib>Timm, Jörg</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thöns, Christine</au><au>Senff, Tina</au><au>Hydes, Theresa J</au><au>Manser, Angela R</au><au>Heinemann, Falko M</au><au>Heinold, Andreas</au><au>Heilmann, Martin</au><au>Kim, Arthur Y</au><au>Uhrberg, Markus</au><au>Scherbaum, Norbert</au><au>Lauer, Georg M</au><au>Khakoo, Salim I</au><au>Timm, Jörg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugs</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>67</volume><issue>3</issue><spage>462</spage><epage>470</epage><pages>462-470</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><abstract>Graphical abstract After exposure to HCV the majority of PWID develop chronic HCV infection that can lead to liver cirrhosis and hepatocellular carcinoma. A small subgroup of PWID is able to clear HCV infection before and after seroconversion. PWID with multiple Bw4 alleles are more likely to clear HCV prior to seroconversion than PWID with one or no Bw4 allele. In addition PWID that encode both KIR3DL1 and a Bw4 80(T) motif have higher chances of spontaneously clearing HCV after seroconversion.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28412292</pmid><doi>10.1016/j.jhep.2017.03.040</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1578-8163</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8278 |
| ispartof | Journal of hepatology, 2017-09, Vol.67 (3), p.462-470 |
| issn | 0168-8278 1600-0641 |
| language | eng |
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| source | Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list) |
| subjects | Adolescent Adult Aged Copy number Female Flow cytometry Gastroenterology and Hepatology Gene Dosage Genotype Genotype & phenotype Genotypes HCV Hepatitis Hepatitis C Hepatitis C - immunology Histocompatibility antigen HLA HLA-B Antigens - genetics Humans Immunoglobulin-like receptors Injections Killer cell immunoglobulin-like receptor Killer cell immunoglobulin-like receptors Killer Cells, Natural - immunology KIR3DL1 Ligands Logistic Models Male Middle Aged Natural killer cells NK cell Potassium channels (inwardly-rectifying) Receptor mechanisms Receptors, KIR3DL1 - genetics Receptors, KIR3DL1 - physiology Ribonucleic acid RNA RNA, Viral - blood Seroconversion Substance Abuse, Intravenous - immunology Substance Abuse, Intravenous - virology Young Adult |
| title | HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugs |
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