A New Fawcettimine-Related Alkaloid from Lycopodium japonicum

A new fawcettimine-related alkaloid, 17α-methyllycoflexine ( 1 ), together with 14 known analogues, was isolated from the whole plants of Lycopodium japonicum Thunb. Their structures were established by extensive spectroscopic analysis, including NMR and HR-EI-MS experiments. Compound 1 is the secon...

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Bibliographic Details
Published in:Chemistry of natural compounds 2018-07, Vol.54 (4), p.729-731
Main Authors: Yang, Qian, Zhu, Yuquan, Zhan, Rui, Chen, Ye-gao
Format: Article
Language:English
Subjects:
Alkaloids
Glucosidase
Herbal medicine
Medicinal plants
Medicine
NMR
Nuclear magnetic resonance
Organic Chemistry
Pharmacy
Plant Sciences
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Summary:A new fawcettimine-related alkaloid, 17α-methyllycoflexine ( 1 ), together with 14 known analogues, was isolated from the whole plants of Lycopodium japonicum Thunb. Their structures were established by extensive spectroscopic analysis, including NMR and HR-EI-MS experiments. Compound 1 is the second example of derivatives of lycoflexine with an unprecedented additional methyl group at C-17. All the isolated alkaloids were assayed for α-glucosidase inhibitory activity. Only lycodine showed weak α-glucosidase inhibitory activity, whereas the other alkaloids showed no activity.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-018-2456-2