Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15

• Published in: Journal of hepatology 2017-06, Vol.66 (6), p.1182-1192
• Main Authors: Zhou, Mei, Luo, Jian, Chen, Michael, Yang, Hong, Learned, R. Marc, DePaoli, Alex M, Tian, Hui, Ling, Lei
• Format: Article
• Language: English
• Subjects: Alanine; Alanine transaminase; Alkaline phosphatase; Animal models; Animals; Aspartate aminotransferase; ATP Binding Cassette Transporter, Subfamily B - deficiency; ATP Binding Cassette Transporter, Subfamily B - genetics; ATP-Binding Cassette Sub-Family B Member 4; Bile; Bile acids and salts; Bile Acids and Salts - biosynthesis; Biological activity; Body composition; Body weight; Carcinogenesis - metabolism; Carcinoma, hepatocellular; Cholangitis; Cyp7a1; Diabetes mellitus; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; Diet; Drug resistance; Energy expenditure; FGF15; FGF19; Fibroblast growth factors; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Gastroenterology and Hepatology; Gene transfer; Glucose; Glycated Hemoglobin - metabolism; Hemoglobin; Hepatocellular carcinoma; Homeostasis; Humans; Hyperglycemia - metabolism; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - pathology; Liver cancer; Liver diseases; Liver Neoplasms, Experimental - etiology; Liver Neoplasms, Experimental - metabolism; Male; Metabolic diseases; Metabolic disorders; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Multidrug resistance; Obesity; Obesity - metabolism; Oxygen consumption; Receptors, cytoplasmic and nuclear; Receptors, Cytoplasmic and Nuclear - agonists; Receptors, Cytoplasmic and Nuclear - metabolism; Receptors, Leptin - genetics; Safety; Serum levels; Species Specificity; STAT3 Transcription Factor - metabolism; Tumorigenicity
• ISSN: 0168-8278; 1600-0641
• DOI: 10.1016/j.jhep.2017.01.027

Graphical abstract