Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence

In 785 mother–child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems....

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Bibliographic Details
Published in:Development and psychopathology 2018-08, Vol.30 (3), p.1145-1156
Main Authors: Barker, Edward D., Cecil, Charlotte A. M., Walton, Esther, Houtepen, Lotte C., O'Connor, Thomas G., Danese, Andrea, Jaffee, Sara R., Jensen, Sarah K. G., Pariante, Carmine, McArdle, Wendy, Gaunt, Tom R., Relton, Caroline L., Roberts, Susanna
Format: Article
Language:English
Subjects:
Adolescence
Adolescent
Adolescents
Age
Brain research
Child
Child & adolescent mental health
Child Behavior Disorders - etiology
Child development
Cognitive ability
Cytokines
Deoxyribonucleic acid
DNA
DNA methylation
Epidemiology
Epigenetics
Female
Gene expression
Humans
Hypotheses
Immune system
Inflammation
Inflammation - complications
Laboratories
Male
Mental disorders
Mental Health
Mental health care
Pregnancy
Prospective Studies
Risk Factors
Special Issue Articles
Stress
Teenagers
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Summary:In 785 mother–child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7–15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7–15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health.
ISSN:0954-5794
1469-2198
DOI:10.1017/S0954579418000330