A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice

This work represents the first broad study of testing diverse heterogenous glycoconjugates (7 different glycoalbumins) for their differential in vivo binding (11 different cancer cell types) in both cell- and animal-based studies. As a result, various changes in biodistribution, excretion, and even...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (63), p.8693-8696
Main Authors: Ogura, Akihiro, Urano, Sayaka, Tahara, Tsuyoshi, Nozaki, Satoshi, Sibgatullina, Regina, Vong, Kenward, Suzuki, Takehiro, Dohmae, Naoshi, Kurbangalieva, Almira, Watanabe, Yasuyoshi, Tanaka, Katsunori
Format: Article
Language:English
Subjects:
Adhesion
Excretion
Glycan
In vivo methods and tests
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Summary:This work represents the first broad study of testing diverse heterogenous glycoconjugates (7 different glycoalbumins) for their differential in vivo binding (11 different cancer cell types) in both cell- and animal-based studies. As a result, various changes in biodistribution, excretion, and even tumor adhesion were observed. Screening a diverse set of heterogeneous glycoalbumins for binding to several cancer cell types in cell- and mouse-based assays.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc01544a