Detection of bisphenol A and derivatives in human urine via cyclodextrin-promoted fluorescence modulation

Reported herein is the sensitive and selective detection of bisphenol A (BPA) and six BPA derivatives in buffer and urine environments. This detection system relies on the ability of γ-cyclodextrin to act as a supramolecular scaffold to promote highly analyte-specific, proximity-induced fluorescence...

Full description

Saved in:
Bibliographic Details
Published in:Analytical methods 2018-01, Vol.10 (30), p.3783-3790
Main Authors: DiScenza, Dana J., Lynch, Julie, Feder, Ezra, Levine, Mindy
Format: Article
Language:English
Subjects:
Analytical chemistry
Bisphenol A
Buffers
Chemical compounds
Cyclodextrin
Cyclodextrins
Derivatives
Detection limits
Discriminant analysis
Fluorescence
Fluorophores
Human wastes
Modulation
Phenols
Urine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Reported herein is the sensitive and selective detection of bisphenol A (BPA) and six BPA derivatives in buffer and urine environments. This detection system relies on the ability of γ-cyclodextrin to act as a supramolecular scaffold to promote highly analyte-specific, proximity-induced fluorescence modulation of high quantum yield fluorophores, which led to unique modulation responses for each cyclodextrin–analyte–fluorophore combination investigated in both buffer and urine environments, and high selectivity between structurally similar analytes using linear discriminant analysis of the resulting response signals. This method was sensitive (low micromolar detection limits), selective (able to differentiate between structurally similar analytes), and broadly applicable (with successful detection in both buffer and urine environments), and has significant potential in the detection of BPA and its derivatives in a wide variety of complex environments.
ISSN:1759-9660
1759-9679
DOI:10.1039/C8AY00733K