Strategy of an in vivo Study of the Evolution of Drugs via X-Ray Diffraction with Synchrotron Radiation

A new approach to the diagnostics of the evolution of drugs in a living organism by means of synchrotron X-ray radiation diffractometry is proposed. A drug is first localized via differential radiography, and a microbeam is then used to obtain the X-ray diffraction patterns of the corresponding area...

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Bibliographic Details
Published in:Bulletin of the Russian Academy of Sciences. Physics 2018-07, Vol.82 (7), p.895-897
Main Authors: Sharafutdinov, M. R., Tolochko, B. P., Kuper, K. E., Ancharov, A. I.
Format: Article
Language:English
Subjects:
Bismuth
Diffraction
Diffraction patterns
Evolution
Hadrons
Heavy Ions
In vivo methods and tests
Microbeams
Nuclear Physics
Physics
Physics and Astronomy
Radiography
Stomach
Synchrotron radiation
X-ray diffraction
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Summary:A new approach to the diagnostics of the evolution of drugs in a living organism by means of synchrotron X-ray radiation diffractometry is proposed. A drug is first localized via differential radiography, and a microbeam is then used to obtain the X-ray diffraction patterns of the corresponding area. Bismuth tripotassium dicytrate (BTD) is used as a test material. It is both introduced inside a stomach of a mouse and used in experiments with a phantom. It is shown experimentally and theoretically that an energy of 90.5 keV near the K -edge of bismuth is most effective in this approach. The possibility applying it to the diagnostics of a human body is demonstrated.
ISSN:1062-8738
1934-9432
DOI:10.3103/S1062873818070353