Rheological properties of brushes on cancerous epithelial cells under the influence of an external oscillatory force

The rheological properties of brushes of different length on the surface of human epithelial cancerous cells are studied here by means of coarse grained numerical simulations, where the surface of the cell is subjected to an external oscillatory force acting on the plane of the cell surface. We mode...

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Bibliographic Details
Published in:arXiv.org 2015-09
Main Authors: Hernández Velázquez, J D, Mejía-Rosales, S, A Gama Goicochea
Format: Article
Language:English
Subjects:
Atomic force microscopes
Atomic force microscopy
Brushes
Coefficient of friction
Complex systems
Computer simulation
Mathematical models
Rheological properties
Rheology
Viscosity
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Summary:The rheological properties of brushes of different length on the surface of human epithelial cancerous cells are studied here by means of coarse grained numerical simulations, where the surface of the cell is subjected to an external oscillatory force acting on the plane of the cell surface. We model explicitly the tip of an atomic force microscope and the cancerous cell as a surface covered by brushes of different length, and take into account the interactions of the brush chains with the tip and with each other, leading to complex rheological behavior as displayed by the profiles of viscosity and the friction coefficient of this complex system. We comment briefly on how these findings can help in the experimental effort to understand the nature of the cancer growth in human epithelial cells.
ISSN:2331-8422