Myosin-II dependent cell contractility contributes to spontaneous nodule formation of mesothelioma cells

We demonstrate that characteristic nodules emerge in cultures of several malignant pleural mesothelioma (MPM) cell lines. Instead of excessive local cell proliferation, the nodules arise by Myosin II-driven cell contractility. The aggregation process can be prevented or reversed by suitable pharmaco...

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Bibliographic Details
Published in:arXiv.org 2015-06
Main Authors: Tárnoki-Zách, Julia, Dona Greta Isai, Méhes, Elod, Paku, Sándor, Neufeld, Zoltán, Hegedus, Balázs, Döme, Balázs, Czirok, Andras
Format: Article
Language:English
Subjects:
Maxwell fluids
Mesothelioma
Morphology
Myosin
Nodules
Pharmacology
Stability
Stability analysis
Substrates
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Summary:We demonstrate that characteristic nodules emerge in cultures of several malignant pleural mesothelioma (MPM) cell lines. Instead of excessive local cell proliferation, the nodules arise by Myosin II-driven cell contractility. The aggregation process can be prevented or reversed by suitable pharmacological inhibitors of acto-myosin contractility. A cell-resolved elasto-plastic model of the multicellular patterning process indicates that the morphology and size of the nodules as well as the speed of their formation is determined by the mechanical tension cells exert on their neighbors, and the stability of cell-substrate adhesion complexes. A linear stability analysis of a homogenous, self-tensioned Maxwell fluid indicates the unconditional presence of a patterning instability.
ISSN:2331-8422