Triple-negative breast cancers: Are they always different from nontriple-negative breast cancers? An experience from a tertiary center in India

BACKGROUND: Triple-negative breast cancers (TNBCs) are known for early age at presentation, large tumor sizes, and overall poor prognosis. However, Indian studies are scarce with limited follow-up data. Hence, the present study is aimed at characterizing nonmetastatic TNBC patients in our population...

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Bibliographic Details
Published in:Indian journal of cancer 2017-10, Vol.54 (4), p.658-663
Main Authors: Suhani, Parshad, Rajinder, Kazi, Mufaddal, Seenu, V, Mathur, Sandeep, Dattagupta, Siddharth, Haresh, K
Format: Article
Language:English
Subjects:
Age
Analysis
Biology
Breast cancer
Cancer therapies
Care and treatment
Chemotherapy
Epidermal growth factor
Gene expression
Medical prognosis
Metastasis
Patient outcomes
Patients
Survival analysis
Treatment outcome
Triple negative breast cancer
Tumors
Womens health
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Summary:BACKGROUND: Triple-negative breast cancers (TNBCs) are known for early age at presentation, large tumor sizes, and overall poor prognosis. However, Indian studies are scarce with limited follow-up data. Hence, the present study is aimed at characterizing nonmetastatic TNBC patients in our population and comparing their outcome with non-TNBC subset. METHODOLOGY: This is a retrospective observational study of nonmetastatic breast cancer patients accrued over 14 years. The demographic, clinical, and pathological profiles of TNBCs and their patterns of recurrences and survivals were compared to that of non-TNBC. Overall and disease-free survival (DFSs) were calculated from the time of initiation of therapy to the occurrence of event, i.e., death or recurrence. RESULTS: TNBC constituted 21.8% of all patients. Patients with triple-negative subtype were significantly younger and more likely to be premenopausal. Higher proportion of TNBC presented in locally advanced stage and had a higher proportion of node-positive patients compared to their non-TNBC counterparts. Although taxane-based neoadjuvant therapy was associated with significantly higher pathological complete responses, recurrences occurred earlier in TNBC. Even though inferior overall and DFSs were encountered in TNBC, statistical significance could not be derived. CONCLUSIONS: TNBCs are a subset of tumors with a poorly understood tumor biology and behavior. Despite being labeled as having an aggressive tumor biology and behavior, not many differences are seen in their clinical outcomes when they present as locally advanced cases.
ISSN:0019-509X
1998-4774
DOI:10.4103/ijc.IJC_348_17