Abnormal uterine bleeding in women receiving direct oral anticoagulants for the treatment of venous thromboembolism

Abstract Abnormal uterine bleeding (AUB) is a common complication of anticoagulant therapy in premenopausal women affected with acute venous thromboembolism. AUB impacts quality of life, and can lead to premature cessation of anticoagulation. There is increasing data to suggest that the direct oral...

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Bibliographic Details
Published in:Vascular pharmacology 2017-08, Vol.93-95, p.1-5
Main Authors: Godin, Richard, Marcoux, Violaine, Tagalakis, Vicky
Format: Article
Language:English
Subjects:
Abnormal uterine bleeding
Administration, Oral
Anticoagulants
Anticoagulants - administration & dosage
Anticoagulants - adverse effects
Bleeding
Blood Coagulation - drug effects
Cardiovascular
Direct oral anticoagulant
Female
Hemorrhage
Humans
Literature reviews
Menstruation
Menstruation - drug effects
Observational Studies as Topic
Quality of life
Randomized Controlled Trials as Topic
Reproductive system
Risk Assessment
Risk Factors
Thromboembolism
Treatment Outcome
Uterine Hemorrhage - blood
Uterine Hemorrhage - chemically induced
Uterine Hemorrhage - physiopathology
Uterus
Venous thromboembolism
Venous Thromboembolism - blood
Venous Thromboembolism - diagnosis
Venous Thromboembolism - drug therapy
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Summary:Abstract Abnormal uterine bleeding (AUB) is a common complication of anticoagulant therapy in premenopausal women affected with acute venous thromboembolism. AUB impacts quality of life, and can lead to premature cessation of anticoagulation. There is increasing data to suggest that the direct oral anticoagulants when used for the treatment of venous thromboembolism differ in their menstrual bleeding profile. This article aims to review the existing literature regarding the association between AUB and the direct oral anticoagulants and make practical recommendations.
ISSN:1537-1891
1879-3649
DOI:10.1016/j.vph.2017.05.001