Ferric Chloride-catalyzed Synthesis of 2-Oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate Derivatives and Their Biological Evaluation

A new methodology has been developed for the synthesis of novel 2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylates from 2-aminonicotinaldehyde, Meldrum’s acid, and the corresponding alcohols in the presence of anhydrous iron(III) chloride as a cheap and readily available catalyst. The structure of t...

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Bibliographic Details
Published in:Russian journal of general chemistry 2018-06, Vol.88 (6), p.1224-1227
Main Authors: Sakram, B., Madhu, P., Sonyanaik, B., Rambabu, S., Ravi, D., Kurumanna, A.
Format: Article
Language:English
Subjects:
Alcohols
Carboxylates
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Ciprofloxacin
Derivatives
Ferric chloride
Fungicides
Heterocyclic compounds
Iron chlorides
Iron compounds
NMR
Nuclear magnetic resonance
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Summary:A new methodology has been developed for the synthesis of novel 2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylates from 2-aminonicotinaldehyde, Meldrum’s acid, and the corresponding alcohols in the presence of anhydrous iron(III) chloride as a cheap and readily available catalyst. The structure of the synthesized compounds was established by IR, 1 H NMR, and mass spectral data and elemental analyses. All the synthesized compounds were evaluated for their in vitro antibacterial and antifungal activity, and the activity of some derivatives was comparable with the activity of Ciprofloxacin and Nystatin used as reference drugs.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363218060294