Dimerization of Pheophorbide а with Activated Carboxylic Group in the Reaction with Ethylenediamine

The interaction of ethylenediamine with pheophorbide a, carboxylic group of the latter being activated with di- tert -butyl dicarbonate, has been studied. Acylation of two amino groups of ethylenediamine with activated pheophorbide a and the formation of phorbine-phorbine dimer with the macrocycles...

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Bibliographic Details
Published in:Russian journal of general chemistry 2018-06, Vol.88 (6), p.1133-1137
Main Authors: Belykh, D. V., Malshakova, M. V.
Format: Article
Language:English
Subjects:
Acylation
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Dimerization
Dimers
Ethylenediamine
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Summary:The interaction of ethylenediamine with pheophorbide a, carboxylic group of the latter being activated with di- tert -butyl dicarbonate, has been studied. Acylation of two amino groups of ethylenediamine with activated pheophorbide a and the formation of phorbine-phorbine dimer with the macrocycles bound in the dimer via amide bonding with ethylenediamine bridge have been demonstrated. It has also be found that the phorbine-phorbine dimer is formed even in large excess of ethylenediamine with respect to pheophorbide a .
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363218060142