A Simple “Green” Synthesis of Novel Bis(3-aryl-1,8-naphthyridin-2-yl)sulfanes and 2-(Methylthio)-3-aryl-1,8-naphthyridines under Microwave Irradiation and Conventional Conditions

An eco-friendly and highly efficient synthesis of substituted bis(3-aryl-1,8-naphthyridin-2-yl)-sulfanes and 2-(methylthio)-3-aryl-1,8-naphthyridines under microwave and conventional conditions. The products are obtained with high yields and purity within short reaction time. The synthesized derivat...

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Bibliographic Details
Published in:Russian journal of general chemistry 2018-06, Vol.88 (6), p.1232-1237
Main Authors: Ravi, D., Ashok, K., Rambabu, S., Sakram, B., Shyam, P.
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Aromatic compounds
Biological activity
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Deoxyribonucleic acid
DNA
Microorganisms
Molecular docking
Reaction time
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Summary:An eco-friendly and highly efficient synthesis of substituted bis(3-aryl-1,8-naphthyridin-2-yl)-sulfanes and 2-(methylthio)-3-aryl-1,8-naphthyridines under microwave and conventional conditions. The products are obtained with high yields and purity within short reaction time. The synthesized derivatives are screened for anti-microbial activity against bacteria and fungi. Molecular docking of the synthesized compounds with DNA Gyrase is studied.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363218060312