Multilayer Bacteriostatic Coating for Surface Modified Titanium Implants

One of the serious problems occurring after the insertion of implants is the formation of biofilms. This leads to implant loss or sepsis. The multilayer coating developed in this study addresses the problems pertaining to bacterial growth and biofilm formation by two different approaches viz. preven...

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Bibliographic Details
Published in:Physica status solidi. A, Applications and materials science Applications and materials science, 2018-08, Vol.215 (15), p.n/a
Main Authors: Vögeling, Hendrik, Duse, Lili, Seitz, Benjamin Sebastian, Plenagl, Nikola, Wojcik, Matthias, Pinnapireddy, Shashank Reddy, Bakowsky, Udo
Format: Article
Language:English
Subjects:
antiadhesive
antibacterial
Biocompatibility
Biodegradability
Biofilms
Chitosan
Coating
Dental implants
Glycolic acid
layer by layer
Multilayers
Nanoparticles
Norfloxacin
Polymers
surface modification
Surgical implants
Titanium
titanium implants
Transplants & implants
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Summary:One of the serious problems occurring after the insertion of implants is the formation of biofilms. This leads to implant loss or sepsis. The multilayer coating developed in this study addresses the problems pertaining to bacterial growth and biofilm formation by two different approaches viz. preventing bacterial adhesion by nanostructured surface modification and by modification of the titanium surface by creating an ultra‐thin poly(lactic‐co‐glycolic acid) (PLGA)/norfloxacin (NFX) nanoparticle coating. In this study, NFX loaded PLGA nanoparticles are used to coat titanium surfaces using the layer by layer method alternating with chitosan. The advantages of biodegradable polymers like PLGA and chitosan to create an anti‐adhesive and antibacterial coating are utilised. The polymers in this study show a high biocompatibility and are completely degraded within 10 weeks which makes them an excellent choice for use in dental implants and stents. The multilayer coating developed in this study addresses the problems associated with bacterial growth and biofilm formation by two different approaches viz. preventing bacterial adhesion by nanostructured surface modification and by creating an ultra‐thin PLGA/norfloxacin nanoparticle coating on the titanium/implant surface. Multi‐layered norfloxacin loaded PLGA nanoparticles alternating with chitosan are used to coat titanium surfaces.
ISSN:1862-6300
1862-6319
DOI:10.1002/pssa.201700844