Nanoparticles and Liposomes for the Surface Modification of Implants: A Comparative Study of Spraying and Dipping Techniques

• Published in: Physica status solidi. A, Applications and materials science Applications and materials science, 2018-08, Vol.215 (15), p.n/a
• Main Authors: Seitz, Benjamin S., Plenagl, Nikola, Raschpichler, Michael, Vögeling, Hendrik, Wojcik, Matthias, Pinnapireddy, Shashank R., Brüßler, Jana, Bakowsky, Udo
• Format: Article
• Language: English
• Subjects: Dipping; layer‐by‐layer; Liposomes; Medical devices; Medical electronics; Medical materials; Nanoparticles; Norfloxacin; Particle density (concentration); PLGA; Polyurethane resins; Spraying; Surgical implants; tetraether lipids; Transplants & implants
• ISSN: 1862-6300; 1862-6319
• DOI: 10.1002/pssa.201700847

Polysiloxane and polyurethane are one of the most commonly employed synthetic polymers for medical devices. Both materials are inexpensive and can be modified easily. The layer‐by‐layer technique is a well‐documented method for surface modification. There are only two ways to modify large surface areas i.e. dipping and spraying. Both methods can be used to create anti‐adhesive, antibacterial and anti‐inflammatory layers. Particle density on the surface is an important parameter for preventing biofilm formation, bacterial adhesion and release of active agents. There should be an optimal number of particles covering the coated surface due to its direct correlation with the release of active agent (per time) and contact area with bacteria. Preliminary studies using regular dipping technique of layer‐by‐layer method have not produced substantial particle densities. Therefore, spraying method is employed using an atomiser to produce a fine mist containing norfloxacin‐loaded nanoparticles and liposomes. An optimal density of particles on the implant surface together with a homogeneous distribution is achieved using this method. Implant polymers need to be modified for prevention of bacterial attachment, biofilm formation and bloodstream infections. A simple and efficient way for surface modification is the layer‐by‐layer technique. Using this method anti‐adhesive, antibacterial and anti‐inflammatory layers can be created. These different layers can be applied by simple yet effective dipping or spraying technique facilitating attachment via electrostatic interactions.