Modeling and Simulation of the Effects of Cyclic Loading on Articular Cartilage Lesion Formation

We present a model of articular cartilage lesion formation to simulate the effects of cyclic loading. This model extends and modifies the reaction-diffusion-delay model by Graham et al. 2012 for the spread of a lesion formed though a single traumatic event. Our model represents "implicitly"...

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Bibliographic Details
Published in:arXiv.org 2013-11
Main Authors: Wang, Xiayi, Ayati, Bruce P, Brouillete, Marc J, Graham, Jason M, Ramakrishnan, Prem S, Martin, James A
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Cartilage
Computer simulation
Cyclic loads
In vivo methods and tests
Knee
Model forms
Online Access:Get full text
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Summary:We present a model of articular cartilage lesion formation to simulate the effects of cyclic loading. This model extends and modifies the reaction-diffusion-delay model by Graham et al. 2012 for the spread of a lesion formed though a single traumatic event. Our model represents "implicitly" the effects of loading, meaning through a cyclic sink term in the equations for live cells. Our model forms the basis for in silico studies of cartilage damage relevant to questions in osteoarthritis, for example, that may not be easily answered through in vivo or in vitro studies. Computational results are presented that indicate the impact of differing levels of EPO on articular cartilage lesion abatement.
ISSN:2331-8422
DOI:10.48550/arxiv.1311.2568