Super-resolution photoacoustic imaging through a scattering wall

Imaging through opaque, highly scattering walls is a long sought after capability with potential applications in a variety of fields. The use of wavefront shaping to compensate for scattering has brought a renewed interest as a potential solution to this problem. A key to the practicality of any ima...

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Bibliographic Details
Published in:arXiv.org 2013-10
Main Authors: Conkey, Donald B, Caravaca-Aguirre, Antonio M, Dove, Jacob D, Ju, Hengyi, Murray, Todd W, Piestun, Rafael
Format: Article
Language:English
Subjects:
Acoustic absorption
Acoustic noise
Acoustics
Feedback
Image resolution
Medical imaging
Optimization
Scattering
Sound diffraction
Sound waves
Wave diffraction
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Summary:Imaging through opaque, highly scattering walls is a long sought after capability with potential applications in a variety of fields. The use of wavefront shaping to compensate for scattering has brought a renewed interest as a potential solution to this problem. A key to the practicality of any imaging technique is the capability to focus light without direct access behind the scattering wall. Here, we address this problem using photoacoustic feedback for wavefront optimization. By combining the spatially non-uniform sensitivity of the ultrasound transducer to the generated photoacoustic waves with an evolutionary competition among optical modes, the speckle field develops a single, high intensity focus significantly smaller than the acoustic focus used for feedback. Notably, this method is not limited by the size of the absorber to form a sub-acoustic optical focus. We demonstrate imaging behind a scattering medium with up to ten times improvement in signal-to-noise ratio (SNR) and five to six times sub-acoustic resolution. The results presented here open up opportunities for 3D imaging applications in the diffusive regime beyond the sound wave diffraction-limited resolution, including medical imaging, photothermal therapy, neuroscience, and optogenetics.
ISSN:2331-8422