Simulation of magnetic active polymers for versatile microfluidic devices

We propose to use a compound of magnetic nanoparticles (20-100 nm) embedded in a flexible polymer (Polydimethylsiloxane PDMS) to filter circulating tumor cells (CTCs). The analysis of CTCs is an emerging tool for cancer biology research and clinical cancer management including the detection, diagnos...

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Bibliographic Details
Published in:arXiv.org 2013-05
Main Authors: Gusenbauer, Markus, Özelt, Harald, Fischbacher, Johann, Reichel, Franz, Exl, Lukas, Bance, Simon, Kataeva, Nadezhda, Binder, Claudia, Brückl, Hubert, Schrefl, Thomas
Format: Article
Language:English
Subjects:
Blood cells
Blood plasma
Cancer
Finite element method
Lab-on-a-chip
Mathematical analysis
Microfluidic devices
Nanoparticles
Polydimethylsiloxane
Polymers
Silicone resins
Simulation
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Summary:We propose to use a compound of magnetic nanoparticles (20-100 nm) embedded in a flexible polymer (Polydimethylsiloxane PDMS) to filter circulating tumor cells (CTCs). The analysis of CTCs is an emerging tool for cancer biology research and clinical cancer management including the detection, diagnosis and monitoring of cancer. The combination of experiments and simulations lead to a versatile microfluidic lab-on-chip device. Simulations are essential to understand the influence of the embedded nanoparticles in the elastic PDMS when applying a magnetic gradient field. It combines finite element calculations of the polymer, magnetic simulations of the embedded nanoparticles and the fluid dynamic calculations of blood plasma and blood cells. With the use of magnetic active polymers a wide range of tunable microfluidic structures can be created. The method can help to increase the yield of needed isolated CTCs.
ISSN:2331-8422
DOI:10.48550/arxiv.1305.7071