Microwave-assisted synthesis of novel benzodifuran-based bis(N-(het)arylthiazol-2-amine) derivatives and their antibacterial and antimycobacterial activities

A new series of 4,4'-(3,5-diphenethylbenzo[1,2- b :5,4- b ']difuran-2,6-diyl)bis( N -(het)arylthiazol-2-amine) derivatives have been synthesized from 1,1'-(3,5-diphenethylbenzo[1,2- b :5,4- b ']difuran-2,6-diyl)diethanone O , O '-diacetyl dioxime and substituted isothiocyana...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2018-06, Vol.54 (6), p.658-663
Main Authors: Kumar Baba, N. H., Ashok, Dongamanti, Rao, Boddu Ananda, Sarasija, Madderla, Murthy, Nandula Y. S.
Format: Article
Language:English
Subjects:
Antibacterial materials
Chemistry
Chemistry and Materials Science
Derivatives
Organic Chemistry
Pharmacy
Pseudomonas aeruginosa
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Summary:A new series of 4,4'-(3,5-diphenethylbenzo[1,2- b :5,4- b ']difuran-2,6-diyl)bis( N -(het)arylthiazol-2-amine) derivatives have been synthesized from 1,1'-(3,5-diphenethylbenzo[1,2- b :5,4- b ']difuran-2,6-diyl)diethanone O , O '-diacetyl dioxime and substituted isothiocyanates under conventional and microwave irradiation conditions. The obtained products were subjected to in vitro antibacterial and antimycobacterial activity tests. Some of the compounds exhibited noteworthy antibacterial activity against Bacillus subtilis (+ve) and Pseudomonas aeruginosa (-ve) strains and antimycobacterial activity against Mycobacterium bovis strain.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-018-2323-x