Microwave-assisted synthesis of novel benzodifuran-based bis(N-(het)arylthiazol-2-amine) derivatives and their antibacterial and antimycobacterial activities

A new series of 4,4'-(3,5-diphenethylbenzo[1,2- b :5,4- b ']difuran-2,6-diyl)bis( N -(het)arylthiazol-2-amine) derivatives have been synthesized from 1,1'-(3,5-diphenethylbenzo[1,2- b :5,4- b ']difuran-2,6-diyl)diethanone O , O '-diacetyl dioxime and substituted isothiocyana...

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Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2018-06, Vol.54 (6), p.658-663
Main Authors: Kumar Baba, N. H., Ashok, Dongamanti, Rao, Boddu Ananda, Sarasija, Madderla, Murthy, Nandula Y. S.
Format: Article
Language:English
Subjects:
Antibacterial materials
Chemistry
Chemistry and Materials Science
Derivatives
Organic Chemistry
Pharmacy
Pseudomonas aeruginosa
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container_title Chemistry of heterocyclic compounds (New York, N.Y. 1965)
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creator Kumar Baba, N. H.
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description A new series of 4,4'-(3,5-diphenethylbenzo[1,2- b :5,4- b ']difuran-2,6-diyl)bis( N -(het)arylthiazol-2-amine) derivatives have been synthesized from 1,1'-(3,5-diphenethylbenzo[1,2- b :5,4- b ']difuran-2,6-diyl)diethanone O , O '-diacetyl dioxime and substituted isothiocyanates under conventional and microwave irradiation conditions. The obtained products were subjected to in vitro antibacterial and antimycobacterial activity tests. Some of the compounds exhibited noteworthy antibacterial activity against Bacillus subtilis (+ve) and Pseudomonas aeruginosa (-ve) strains and antimycobacterial activity against Mycobacterium bovis strain.
doi_str_mv 10.1007/s10593-018-2323-x
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subjects Antibacterial materials
Chemistry
Chemistry and Materials Science
Derivatives
Organic Chemistry
Pharmacy
Pseudomonas aeruginosa
title Microwave-assisted synthesis of novel benzodifuran-based bis(N-(het)arylthiazol-2-amine) derivatives and their antibacterial and antimycobacterial activities
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