Point Defects in Double Helix Induced by Interaction of Silver Nanoparticles with DNA

Interaction of DNA-silver nanoparticles (AgNPs) complexes with H3O+, Cu2+ and Cl- has been studied by spectro-photometric, spectro-fluorimetric and differential scanning micro calorimetric methods. It is shown that DNA is a catalyst in redox reactions taking place in AgNPs adsorbed on its surface. W...

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Bibliographic Details
Published in:arXiv.org 2012-06
Main Authors: Bregadze, Vasil G, Melikishvili, Zaza G, Giorgadze, Tamar G, Monaselidze, Jamlet R, Jaliashvili, Zaza V, Khuskivadze, Temur B
Format: Article
Language:English
Subjects:
Cell death
Copper
Crosslinking
Deoxyribonucleic acid
DNA
Nanoparticles
Photometry
Point defects
Redox reactions
Silver
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Summary:Interaction of DNA-silver nanoparticles (AgNPs) complexes with H3O+, Cu2+ and Cl- has been studied by spectro-photometric, spectro-fluorimetric and differential scanning micro calorimetric methods. It is shown that DNA is a catalyst in redox reactions taking place in AgNPs adsorbed on its surface. We also demonstrate that Ag+ ions that are freed after corrosion of nanoparticles show absorption into the inner part of DNA double helix, i.e. they make the so-called cross-links between complementary base pairs of DNA. The cross-links present point defects of DNA which leads in-vivo to cell death.
ISSN:2331-8422