The joint effect of apolipoprotein E (E)4 and MRI findings on lower-extremity function and decline in cognitive function

Brain MRI (1.5 T), neuropsychological tests, and lower-extremity physical function tests were administered to World War II male veteran twins ages 69 to 80. For the sample as a whole, the comparison of subjects by median split of total cerebral brain volume found that those with brain volumes below...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2000-02, Vol.55A (2), p.M103
Main Authors: Carmelli, Dorit, DeCarli, Charles, Swan, Gary E, Kelly-Hayes, Maggie
Format: Article
Language:English
Subjects:
Cognition & reasoning
Legs
Motor ability
Neurology
Older people
Online Access:Get full text
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Summary:Brain MRI (1.5 T), neuropsychological tests, and lower-extremity physical function tests were administered to World War II male veteran twins ages 69 to 80. For the sample as a whole, the comparison of subjects by median split of total cerebral brain volume found that those with brain volumes below the median performed worse on tests of gait and balance (p less than .01) and experienced greater cognitive decline on the MMSE and BVRT cognitive test batteries (both p less than .01).
ISSN:1079-5006
1758-535X